ESPE Abstracts (2015) 84 P-3-1136

Menstruation Pattern in Idiopathic Central Precocious Puberty Girls after Discontinuing GnRH Agonist Therapy

Rapeepun Chai-udoma, Suttipong Wacharasindhua & Tassawan Rungruxsirivornb


aDepartment of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; bDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand


Background: GnRH agonist (GnRHa) has been used in treatment of idiopathic central precocious puberty (ICPP) girls for more than 20 years. However, the menstruation pattern after discontinuation of treatment has been rarely reported.

Objective and hypotheses: To evaluate menstrual patterns in ICPP girls after discontinuing GnRHa therapy.

Method: Menstrual diary was recorded for 3 consecutive months by ICPP girls after discontinuation of treatment and normal healthy girl was a control group.

Results: Sixty-two ICPP girls were treated with GnRHa 3.75 mg s.c. injection every 4 weeks at a mean age of 7.9±1.5 years. The duration of treatment was 2.3±1.6 years. Menstruation developed at14.0±6.0 months after discontinuing GnRH a therapy at a mean age of 11.8±1.5 years. Normal healthy girls had a mean menarcheal age of 11.3±2.0 years. The percentage of subjects with irregular menstrual pattern was significantly higher in ICPP girls than the control group (67.9% vs 23.4%, P<0.001) during the first gynaecological year but this was not different in the second gynaecological year (30.4% vs 27.8%). Final BMI SDS in ICPP girls was significantly higher than that of control (0.84±1.35 vs 0.2±1.48, P<0.001) but not reach over weight criteria.

Conclusion: Irregular menstrual patterns in ICPP girls previously treated with GnRH agonist therapy are observed only during the first gynaecological year.

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