Background: Among autoimmune disorders, autoimmune thyroid diseases are the most prevalent pathologies associated with premature ovarian failure.
Objective and hypotheses: We aimed to investigate the ovarian function and reserve in euthyroid adolescents (TSH<2.5 mIU/l) diagnosed with Hashimoto thyroiditis (HT).
Method: 30 adolescent girls (mean age 15.1±1.4 years) newly diagnosed as HT with presence of high thyroid antibodies with gland heterogeneity in ultrasound and age-matched 30 healthy female subjects were enrolled the study. Anti-ovarian antibody, LH/FSH ratio, estradiol, anti-mullarian hormone (AMH), inhibin-B, and total testosterone were measured and the follicle count, ovarian volumes and uterine length were evaluated using pelvic ultrasound.
Results: All patients were euthyroid and had normal thyroid volume. 33% (n: 10) of the patients had higher ovarian antibody above the limits without any ovarian dysfunction. There was no significant difference between the girls with HT and healthy controls regarding LH/FSH ratio, estradiol and inhibin-B levels. Anti-ovarian antibody (365±311 vs 168.8±148 ng/ml, P: 0.022), AMH (P: 0.007) and total testosterone levels were higher in HT group than the control group (P: 0.003). There were no significant mean measurements for total ovarian follicle count, total ovarian volume and uterine length between the groups. Anti-ovarian antibody was found to be positively correlated with LH/FSH ratio (r: 0.271, P: 0.036), AMH (r: 0.845, P: 0.0001) and inhibin-B (r: 0.633, P: 0.0001) in HT group.
Conclusion: This study demonstrated that the HT girls had normal ovarian reserves based on measurements of AMH, inhibin B, FSH, LH/FSH ratio, estradiol and ovarian follicle counts.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology