Objective: Recent experimental data suggest that circulating serotonin interacts with bone metabolism, although this is less clear in humans. This study investigated whether serum serotonin interferes with bone metabolism in young women with anorexia nervosa (AN), a clinical model of energy deprivation.
Methods: Serum serotonin, markers of bone turnover (osteocalcin (OC), procollagen type 1 N-terminal propeptide (PINP), type 1-C telopeptide breakdown products (CTX)), leptin, soluble leptin receptor (sOB-R), and IGF1 and its binding protein (IGFBP3) were assessed. Whole body, spine, hip and radius areal bone mineral density (aBMD) were assessed by dual-energy x-ray absorptiometry in 21 patients with AN and 19 age-matched controls.
Results: Serum serotonin, leptin, IGF1, IGFBP3, OC, PINP and aBMD at all sites, radius excepted, were significantly reduced in AN whereas CTX and sOB-R were increased compared with controls. Serum serotonin levels were positively correlated with weight, BMI, whole body fat mass, leptin and IGF1, and negatively with CTX for the entire population.
Conclusions: Low serum serotonin levels are observed in patients with AN. Although no direct link between low serum serotonin levels and bone mass was identified in these patients, the negative relationship between serotonin and markers of bone resorption found in all population nevertheless suggests the implication of serotonin in bone metabolism. Impact of low serum serotonin on bone in AN warrants further studies.
Funding: This work was supported by the Centre Hospitalier Regional Universitaire (CHRU) of Montpellier (AOI UF 8751 and UF 8854) and a grant from the Société Française dEndocrinologie Pédiatrique (SFEDP).
01 - 03 Oct 2015
European Society for Paediatric Endocrinology