ESPE Abstracts (2015) 84 P-3-639

Is Serum Serotonin Involved in the Bone Loss of Young Females with Anorexia Nervosa?

Laurent Maimouna,b, Sebastien Guillaumec, Patrick Lefebvred, Pascal Philiberte, Helena Bertetf, Marie-Christine Picotf,g, Laura Gasparih, Françoise Parisd,i, Denis Mariano-Goularta, Eric Renardd,j & Charles Sultani

aDépartement de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHRU) Montpellier, Montpellier, France; bPhysiologie et Médecine Expérimentale du Cœur et des Muscles, Institut National de la Santé et de la Recherche Médicale (INSERM) U1046, UMR9214 CNRS, Université de Montpellier, Montpellier, France; cDépartement d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHRU Montpellier, UMI, INSERM U1061, Montpellier, France; dDépartement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France; eDepartement de Biochimie et d’Hormonologie, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France; fUnité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France; gCIC INSERM 1001, Hôpital Gui de Chauliac, CHRU Montpellier., Montpellier, France; hDépartement de Pédiatrie, Hôpital Caremeau, CHRU Nîmes, Nîmes, France; iDépartement de Pédiatrie, Hôpital Arnaud de Villeneuve, Unité d’Endocrinologie et Gynécologie Pédiatrique, Montpellier, France; jInstitut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661, Montpellier, France

Objective: Recent experimental data suggest that circulating serotonin interacts with bone metabolism, although this is less clear in humans. This study investigated whether serum serotonin interferes with bone metabolism in young women with anorexia nervosa (AN), a clinical model of energy deprivation.

Methods: Serum serotonin, markers of bone turnover (osteocalcin (OC), procollagen type 1 N-terminal propeptide (PINP), type 1-C telopeptide breakdown products (CTX)), leptin, soluble leptin receptor (sOB-R), and IGF1 and its binding protein (IGFBP3) were assessed. Whole body, spine, hip and radius areal bone mineral density (aBMD) were assessed by dual-energy x-ray absorptiometry in 21 patients with AN and 19 age-matched controls.

Results: Serum serotonin, leptin, IGF1, IGFBP3, OC, PINP and aBMD at all sites, radius excepted, were significantly reduced in AN whereas CTX and sOB-R were increased compared with controls. Serum serotonin levels were positively correlated with weight, BMI, whole body fat mass, leptin and IGF1, and negatively with CTX for the entire population.

Conclusions: Low serum serotonin levels are observed in patients with AN. Although no direct link between low serum serotonin levels and bone mass was identified in these patients, the negative relationship between serotonin and markers of bone resorption found in all population nevertheless suggests the implication of serotonin in bone metabolism. Impact of low serum serotonin on bone in AN warrants further studies.

Funding: This work was supported by the Centre Hospitalier Regional Universitaire (CHRU) of Montpellier (AOI UF 8751 and UF 8854) and a grant from the Société Française d’Endocrinologie Pédiatrique (SFEDP).