ESPE Abstracts (2015) 84 P-3-640

Cranial MR Spectrometry Findings of Patients Aged 10-15 Years with Diagnosis of Rickets

Murat Doğana,b, İlyas Aydina,b, Keziban Aslı Balaa,b, Sultan Kabaa,b & Özlem Gulpinara,b

aPediatrics, School of Medicine, Yuzuncu Yil University, Van, Turkey; bPediatrics D, Van Regional Training and Research Hospital, Van, Turkey

Objective: It is known that vitamin D has differential roles in cell proliferation, differentiation, neurotransmission and neuroplasticity in nervous system and exerts neurotrophic and neuroprotective effects, even different functions of vitamin D has been studied by advocating that vitamin D should be classified as a neurosteroid. It has been long known that vitamin D deficiency, VDR dysfunction, hyperparathyroidism and hypervitaminosis are potential causes for sensorineural hearing loss. Here, we aimed to detect pretreatment cranial spectrometry findings in patients with rickets.

Material and method: This study included pretreatment cranial MR spectrometry evaulations of 30 patients (aged 0–15 years) who were diagnosed as rickets in Child Endocrinology department of Yüzüncü Yıl University, Prof. Dr Dursun Odabaş Medical Center between January 2014 and July 2014.

Results: The study included 31 patients diagnosed as rickets. One patient was excluded due to declining participation. All patients underwent cranial MR spectrometry. Mean age was 2.15±4.12 years (min–max: 0.07–15.13) in 30 patients with rickets. There were eight girls (25.8%) and 23 boys (74.2%). When biochemical and hormone values were studied in patients with rickets, the following results were observed: mean calcium value, 8.09±1.52 mg/dl; mean phosphor value, 4.24±1.53 mg/dl; mean magnesium value 1.95±0.23 mg/dl; mean alkaline phosphatase value 838.23±627.86;U/l; mean parathormone value, 314.82±310.76 pg/ml; mean creatinine kinase value, 173.58±239.73;U/l; mean albumin value 4.05±1.41 g/dl; and mean 25 OH vitamin D level 5.52±3.20 ng/ml. The following values were found in cranial MR spectrometry: mean choline, 105.14 (min–max: 5.99–173); mean creatinine, 84.08 (min–max: 2.96–126); N-acetyl aspartate, 127.69 (min–max: 0.01–206); mean choline/creatinine, 1.4 (min–max: 0.74–3.2) and N-acetyl aspartate/creatinine, 1.61 (min–max: 4.04). When cranial spectrometry and biochemical values were assessed by Pearson correlation, a positive correlation was detected between vitamin D level and N-acetyl aspartate/creatinine ratio. It was found that there was negative correlation between calcium level and creatinine value while positive correlation between calcium level and choline/creatinine ratio.

Conclusion: Although this study is conducted on a limited sample size, we think that cranial MR spectrometry findings will provide useful data in monitoring patients with vitamin D deficiency and in studies investigating effects of vitamin D deficiency on brain.

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