ESPE Abstracts (2015) 84 P-3-778

Metabolic Control in Children in Northern Spain DM1A with Deficit of Vitamin D

Ignacio Diez-Lopez, Ainhoa Sarasua-Miranda & Isabel Lorente-Blazquez

H. Universitary of Alava, Vitoria, Spain

Background: 1 000 million people worldwide presenting vitamin D deficiency in children prevalence of vitamin D deficiency in certain regions described up to 80%, especially at high latitudes (above 37). Has been postulated role of vitamin D in the immune system and in clinical variability DM1.

Objective and hypotheses: To study the degree of deficit VITD in our population (Location: 42° 51’north latitude 2° 41’west longitude) with DM1 and check whether this influences the metabolic control.

Method: Prospective open intervention. DM1a with 12 months duration. 1st wave study months April-May 2014 – 6 months intervention (insolation 3 months+3 months treatment) – revaluation Q4 November–December 2014. Intervention three summer months inducing activities ‘outdoors’ and posterior shock treatment 3 months one unidosis 2.5 ml bottle. 25 000 IU of cholecalciferol (vitamin D), equivalent to 0.625 mg. (DELTIUS)/one every 3 weeks. Reference Endocrine Society (2011) Levels of 25-OH-vitamin D (ng/ml), failure<30 (student t), with a confidence interval of 95%. SPSS19.0.

Results: Initially selected 57 cases (26/57♂–46%). Average age debut 8.24aDS4.27 (0.3to15). 11.11% HbA1c debut DS2.37 (8–15.5). Age current average 11.5aDS3.67 (2–17). SDS1.16 average HbA1c 7.95% (5.8–9.6) in 1 wave. No differences between sexes. 93% basal-bolus regimen (4/57 ISCI). 89% Caucasian (3/57 Maghreb, Latin 3/57) 98% in range 25OHD insufficiency average 18 ngr/ml DS (10–28). Normality ♀ caucasian 12a (37 ngr/ml) Intervention in 56 cases. On average HbA1c 7.68% revaluation SDS1.18 (5.6–9.2) P:0.12. Mean 25OHD 33 ng/l DS (26–52) P:0.01. Improvement in 52/56 cases (93%). No differences between sexes or races.

Conclusion: Children DM1 in our region have a severe deficiency of vitamin D. The exercise outdoors in summer and a shock treatment with depot preparations is shaping effective in correcting this deficit. Although no significance in improving metabolic control HbA1c levels seem to improve in these cases. An assessment and comprehensive intervention of this pediatric population is needed compared with a deficit of vitamin D.

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