Background: It has been discussed in literature, that being severely obese and adolescent are predictive for failure in a behavior based weight-loss program.
Objective: To investigate the association between age and initial BMI-SDS with BMI-SDS courses during and after the attendance of an inpatient weight-loss program.
Design: The LOGIC-trial involves overweight and obese children and adolescents (619 years), who participate in an inpatient weight-loss program for 46 weeks. Height and weight values were taken at the start (T0), at the end of the intervention (T1) and one year after start of the intervention (T2). The study sample includes n=1.046 participants (T0). The recall rate at T2 was relatively high (54.6% of the original cohort). Missing BMI values were replaced by baseline observation carried forward method. Age at baseline (years) was grouped: 711 (n=214); 1214 (n=501); ≧15 (n=331). BMI-SDS values at baseline were grouped by using the 75th internal percentile (low vs. high). Linear mixed effects model (piecewise linear function with a knot at T1) was calculated.
Results: BMI-SDS courses are significantly determined by age and BMI-SDS at baseline. Older children (≧15 yrs) improved the least in reducing BMI-SDS under short-term intervention compared to the younger participants (independent of BMI-SDS at baseline). During 1-year follow-up BMI-SDS increased in all participants. The strongest increase was observed in 1214 year-old children with a high BMI-SDS at baseline. 1214 years old children showed the smallest BMI-SDS reduction during FU compared to the younger and older age groups, independent of BMI-SDS at baseline. The BMI-SDS difference (T0T2) was −0.15 in children (1214 years) with a low BMI-SDS and −0.05 in children with a high BMI-SDS at baseline.
Conclusion: Age and BMI-SDS at baseline determine the BMI-SDS courses during and after the attendance of an inpatient weight-loss program. The long-term success of an inpatient weight-loss program was lowest in 1214 years old children.
Funding: The LOGIC-study is funded by the non-profit organization Else Kröner-Fresenius-Stiftung, Bad Homburg, Germany and the German statutory pension insurance scheme, Landshut, Germany.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology