ESPE Abstracts (2015) 84 P-3-843

Increased Glucagon-Like Peptide-1 Response to Oral Glucose in Prepubertal Obese Children

M Loredana Marcovecchio, Nella Polidori, Cosimo Giannini, Tommaso De Giorgis, Francesco Chiarelli & Angelika Mohn


University of Chieti, Chiety, Italy


Background: Over the last years a role for gastrointestinal hormones, such as glucagon-like peptide (GLP-1), in the pathogenesis of obesity and its complications, has been hypothesized. However, there are few data for the paediatric population.

Objective and hypotheses: To assess whether there is a difference in post-load GLP-1 response in obese children compared to normal-weight peers and to assess the relationship with insulin responses.

Method: Ten prepubertal obese children (five boys; mean age (±S.D.): 10.5±1.6 years; BMI-SDS: 2.2±0.5) and ten controls (eight boys; age: 9.9±1.2 years; BMI-SDS: −0.7±0.5) underwent a modified oral glucose tolerance test (OGTT) to evaluate post-load (0–5–10–15–20–30–60–90–120 min) glucose, insulin and GLP-1 responses. Insulin sensitivity (HOMA-IR, WBISI) and secretion (HOMA-ß, insulinogenic index) indexes, area under the curve (AUC) for glucose, insulin and GLP-1 were calculated.

Results: Obese children showed an increased post-load GLP-1 release along with higher AUC insulin and insulin secretion and resistance indexes. GLP-1 AUC was associated with BMI-SDS (r=0.45, P=0.04), HOMA-IR (r=0.53; p=0.01) and fasting glucose (r=0.68; P=0.001).

Table 1 (for abstract P3-843)
Obese groupControl groupP-value
Fasting insulin (μU/ml)15.9±10.66.5±2.00.02
Insulin AUC (μU/ml×120min)8485±4354.83057±1195.30.005
GLP-1 AUC (ng/ml×120 min)505.4±225.6335.2±83.10.04
HOMA-IR3.7±2.51.4±0.40.02
WBISI4.7±2.59.3±2.70.002
HOMA-p3.6±2.41.5±0.50.03
Insulinogenic index4.8±3.80.6±0.40.007

Conclusion: Obese children showed an increased GLP-1 response to oral glucose. The increased GLP-1 response might likely represent a compensatory mechanism to avoid post-prandial hyperglycaemia and allow a normal glucose tolerance.

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