Background: The prevalence of obesity in children and adolescents has increased significantly worldwide with an alarming rise of its co-morbidities. The excess of visceral adipose tissue is associated with hypertension, prothrombotic and pro-inflammatory states leading to cardiovascular diseases.
Aim of the study: To find possible associations between visceral obesity and plasma fibrinogen, as one of the cardiovascular risk factors, in obese children.
Subjects and methods: Our study included 43 obese children and 40 non-obese age and sex matched controls who were subjected to a detailed history taking, complete physical examination, anthropometric assessment, body composition analysis, ultrasonographic measurement of visceral adipose tissue and subcutaneous fat as well as laboratory measurement of plasma fibrinogen.
Results: The present study revealed significant higher levels of fibrinogen in obese children than control (14.5+5.1 mg/ml and 2.9+0.52 respectively) with P-value<0.01. Moreover, the obese group had highly statistical significant differences in visceral fat (5.96+0.77 cm) and subcutaneous fat (2.66+0.70 cm) than control (2.45+0.65 and 0.70+0.18 mg/ml respectively) with P-value<0.01. In addition, fibrinogen had significant positive correlation with BMI (r=0.327), Waist/Hip ratio (r=0.394), fat percentage (r=0.301), visceral adipose tissue (r=0.323) and subcutaneous fat (r=0.301).
Conclusion: There is highly significant increase in the fibrinogen level, visceral and subcutaneous abdominal fat in the obese group than controls with insignificant sex differences. Fibrinogen had significant positive correlation with the different adiposity markers, blood pressure, visceral and subcutaneous fat. Visceral adipose tissue is a stronger predictor for cardiovascular risk compared to subcutaneous fat.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology