ESPE Abstracts (2015) 84 P-3-877

Higher Hb1Ac in Obese Prader-Willi Syndrome Patients vs Obese Controls

Caroline Passone, Tiago Jeronimo dos Santos, Simone Sakura Ito, Marina Ybarra, Louise Cominato, Ruth Franco & Durval Damiani


Instituto Da Criança Do Hospital Das Clinicas Da Faculdade De Medicina Da Universidade De São Paulo, São Paulo, Brazil


Background: Obesity in Prader-Willi Syndrome has peculiar features associated to reduced lean body mass which could confer different metabolic characteristics.

Objective and hypotheses: The aim of this study is to describe and to compare the metabolic profile in obese patients and obese Prader-Willi syndrome patients (OPWS) followed in a Pediatric Endocrinology outpatient clinic.

Method: 45 obese and 22 OPWS patients between 8 and 20 years old were evaluated in a cross-sectional study. We compared them according to cholesterol and triglycerides levels, as well as glycated hemoglobin (A1c) and fasting glucose.

Results: The mean age of the 67 patients was 14.1 (±3.2) years old, 45 are male and the mean z-BMI was +3.1DP (±0.6DP). Both groups did not differ in gender, age and z-BMI. The metabolic profile in OPWS vs obese patients showed: higher LDL-c level (LDL-c≧130 mg/dl) 18.2×11.1%, lower HDL-c level (<40 mg/dl) 36.4×46.7%, and lower hypertriglyceridemia (≧150 mg/dl) 13.6×24.4% respectively; but there was no significant difference between both groups. There was a significant difference (P<0.001) in abnormal Hb1Ac (≧5.8%) between OPWS (73.3%) and obese patients (7.1%). Only one patient in each group had high fasting glucose (>100 mg/dl).

Conclusion: There is a high prevalence in both groups of inappropriate cholesterol levels. Moreover, Hb1Ac could be an important tool to evaluate glycemic profile in OPWS patients.

Article tools

My recent searches

No recent searches.