ESPE Abstracts (2015) 84 P-3-877

Higher Hb1Ac in Obese Prader-Willi Syndrome Patients vs Obese Controls

Caroline Passone, Tiago Jeronimo dos Santos, Simone Sakura Ito, Marina Ybarra, Louise Cominato, Ruth Franco & Durval Damiani

Instituto Da Criança Do Hospital Das Clinicas Da Faculdade De Medicina Da Universidade De São Paulo, São Paulo, Brazil

Background: Obesity in Prader-Willi Syndrome has peculiar features associated to reduced lean body mass which could confer different metabolic characteristics.

Objective and hypotheses: The aim of this study is to describe and to compare the metabolic profile in obese patients and obese Prader-Willi syndrome patients (OPWS) followed in a Pediatric Endocrinology outpatient clinic.

Method: 45 obese and 22 OPWS patients between 8 and 20 years old were evaluated in a cross-sectional study. We compared them according to cholesterol and triglycerides levels, as well as glycated hemoglobin (A1c) and fasting glucose.

Results: The mean age of the 67 patients was 14.1 (±3.2) years old, 45 are male and the mean z-BMI was +3.1DP (±0.6DP). Both groups did not differ in gender, age and z-BMI. The metabolic profile in OPWS vs obese patients showed: higher LDL-c level (LDL-c≧130 mg/dl) 18.2×11.1%, lower HDL-c level (<40 mg/dl) 36.4×46.7%, and lower hypertriglyceridemia (≧150 mg/dl) 13.6×24.4% respectively; but there was no significant difference between both groups. There was a significant difference (P<0.001) in abnormal Hb1Ac (≧5.8%) between OPWS (73.3%) and obese patients (7.1%). Only one patient in each group had high fasting glucose (>100 mg/dl).

Conclusion: There is a high prevalence in both groups of inappropriate cholesterol levels. Moreover, Hb1Ac could be an important tool to evaluate glycemic profile in OPWS patients.

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