Objective: To evaluate the level of 25 (OH) D vitamin in obese adolescents living in the South of Russia.
Materials and method: We examined 20 obese adolescents with varying degrees of severity, aged 15.5±0.3 years, ten girls and boys. The comparison group consisted of ten healthy adolescents matched for age and sex. Obesity was calculated by BMI. Level of 25-(OH) D vitamin was studied in the laboratory by ELISA (nmol/l). Furthermore, the fasting blood glucose, fasting insulin was investigated, insulin resistance index was calculated (HOMA).
Results: Excess body weight was diagnosed in 20% (two) boys and 30% (three) girls (BMI 2530), I degree of obesity (BMI 3035) were detected in 70% (seven) boys and 60% (six) girls, II obesity degree in 10% (one) boys and 10% (one) girls. Level of 25-(OH) D vitamin was significantly lower in the intervention group compared with the control group (25.2±0.12 nmol/l, 63.7±0.24 nmol/l respectively). Thus sex differences havent been identified. In assessing the level of 25-(OH) D vitamin according to WHO classification revealed that 65% (13) of the main group of adolescents had vitamin D deficiency, which amounted to 20.4±0.86 nmol/l. Insulin resistance was detected in all the surveyed boys and girls of the main group, HOMA index was 3.4±0.14. As a result, the correlation analysis was found a positive relationship between the level of 25-(OH) D Vitamin and the degree of obesity, as well as index HOMA.
Conclusion: In adolescents with obesity and insulin resistance showed a reduction in the level of 25-(OH) vitamin D, despite the the South place of residence.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology