Objective: To evaluate the efficacy of the drug Rastan, (manufacturer JSC Pharmstandard-Ufa Vita), in children with GH deficiency at the beginning of treatment at different ages.
Materials and methods: We examined two groups of patients with GH deficiency who receive the drug for 3 years. In group 1, nine boys and two girls with age at debut of therapy 5.88±1.35 (from 3.3 to 7.1 years); in the 2nd group of ten boys and two girls at the beginning of treatment in 10.57±1.76 (from 8.3 to 13.7 years). The diagnosis is established on the basis of the standard stimulus samples, the maximum release of GH in the sample with clonidine in group 1 3.46±2.81 ng/ml were evaluated by growth rate, bone age S.D.s of growth.
Results: At the start of treatment age in group 1 5.88±1.35, bone age 2.39±0.56, S.D.s growth 4.11±0.83; respectively in group 2, the patients age 10.57±1.76, bone age 6.87±2.0 S.D.s growth 3.201±0.34. For 1 year of treatment, the growth rate in group 1 amounted 8.04±3.30 cm, in group 2 9.05 of 2.72 cm, which has no significant differences (P=0.75). S.D.s of growth did not change significantly and amounted to −3.48±0.97 cm (P=0.28) in group 1, −2.82±38 cm (P=0.077) in group 2. For 3 years in the growth one and group 2 added 23.46±6.87 cm and 22.30±6.44 cm (P=0.28) respectively. SDs growth decreased from −4.11±0.83 cm to −2.43±1.139 cm (P=0.007) in group 1 and in group 2 with-3.20±1.34 cm to −2.02±1.21 cm (P=0.045). Bone age increased in group 1 comparison with 2.39±0.56 to 5.76±1.57 (P=0.007) and in group 2 with 6.87±2.0 to 11.01±1.91 (P=0.013).
Conclusions: These clinical observations demonstrate a significant effect of the drug Rastan in the treatment of GH deficiency by children for 3 years regardless of the age of the patients at the beginning of therapy. Experience of the use of genetically engineered GH Rastan by children in clinical practice.
01 - 03 Oct 2015
European Society for Paediatric Endocrinology