ESPE Abstracts (2016) 86 P-P2-279

Mucormycosis and Type 1 Diabetes: A Case Report

Erdal Erena, Solmaz Celebib, Enes Salib, Tuncay Topacc & Omer Tarima

aUludag University, School of Medicine, Department of Pediatric Endocrinology, Bursa, Turkey; bUludag University, School of Medicine, Department of Pediatric Infectious Disease, Bursa, Turkey; cUludag University, School of Medicine, Department of Medical Mycology and Microbiology, Bursa, Turkey

Background: Mucormycosis which is an invasive fungal disease and commonly seen in immunocompromised patients is very rare in the diabetic children.

Case report: We present a case with type 1 diabetes with mucormycosis. A 14-year-old male patient was referred to our department due to polyuria, polydipsia, weight loss, headache, altered consciousness, fever, and rhinorrhea. After the diabetic ketoasidosis treatment, left facial paralysis, anisocoria, and ptosis were noted. MRI revealed fronthoethmoid fungal sinusitis, orbital cellulitis, frontobasal cerebritis and abscess formation. Mucormycosis was confirmed by biopsy. Amphoterisin B and posaconasol treatment were started. Hyperbaric oxygen treatment as adjuvant was commenced as well. Regression of fungal lesions were demonstrated by MRI. The patient is still on oral posaconasol treatment which is planned to continue for 1 year. He is followed up by neurologically for unilateral vision loss and facial paralysis.

Conclusion: It should be kept in mind that untreated or uncontrolled diabetes causes immune deficiency which is a risk for mucormycosis. Early detection and treatment of mucormycosis is very important to reduce morbidity and mortality.

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