Background: Alterations in endocrine functions and low-grade systemic inflammation represent fundamental characteristics of obesity. These biological systems have been repeatedly linked to fatigue symptoms.
Objective and hypotheses: The aim of the study was to assess the relationship between fatigue symptoms and metabolic/inflammatory markers in a sample of non-diabetic obese children.
Method: The study was conducted in 41 obese (median BMI-SDS 4.2 (2575th percentiles: 3.65.1)) children, median aged 12 (915) years, recruited in a pediatric tertiary center. Three dimensions of fatigue were assessed using the Pediatic Quality of Life Inventory Multidimentional Fatigue Scale: general fatigue, sleep/rest, cognitive fatigue. Moreover, a principal component analysis extracted relevant additional symptom dimensions (concentration, energy, self-perceived cognitive efficiency, sleep/rest and motivation/anhedonia).
Results: Cognitive fatigue dimension and reduced motivation/anhedonia dimension were both associated with BMI, independently of sex and age. Cognitive fatigue was correlated to insulin concentration and HOMA. Reduced motivation/anhedonia was correlated to insulin concentration, HOMA, uric acid and hs-CRP concentrations. The association with insulin concentration and HOMA persisted when BMI was taken into account.
Conclusion: Among several fatigues dimensions, specific dimensions of cognitive fatigue and reduced motivation/anhedonia relate to insulin resistance in non-diabetic obese children.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology