Background: Thyroid dysfunction plays an important role in formation of dyslipidemia during obesity while thyroid pathology (TP) is one of the most common endocrinopathies associated with obesity. Among adults existence of gender differences has been proven in formation of a dyslipoproteiniaemias and thyropathies; the presence of such changes in obese children requires clarification.
Objective and hypotheses: To explore the details of blood lipids in children with obesity depending on the functional state of the thyroid and sex.
Method: In 187 children with obesity, age 618 years (105 boys, 82 girls) the following blood lipids indicators were studied total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG). Data were analyzed according to gender and the presence of hypothyroidism, taking indicators of thyroid hormones into account (1gr TSH>4.0 mIU/ml, 2 gr TSH<4.0 mIU/ml).
Results: Atherogenic lipid level changes were detected more frequently in patients of 1gr (increase of TG level in 35.7%, reduction of HDL level in 42.8% of patients) compared to 2 gr (16.7% and 22.2% respectively, P<0.05). These results were confirmed by the difference between average rates of TG (1.15±0.37 mmol/l in 1 gr vs. 1.07±0.31 mmol/l in 2 gr) and LDL (2.72±0.48 mmol/l in 1 gr vs. 2.51±0.43 mmol/l in 2 gr), P<0.05. In the 1 gr such shifts were more typical of boys than girls: TG 1.23±0.58 vs. 1.08±0.48 mmol/l, LDL 2.93±0.61 vs. 2.55±0.43 mmol/l, P<0.05. In 2 gr such differences have not been identified and changes in average HDL levels were less pronounced.
Conclusion: Formation of atherogenic dyslipidemia in children with obesity is closely associated with hypothyroidism, especially in boys. This requires particularly careful monitoring of thyroid hormone indicators and blood lipids in this group of patients.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology