ESPE Abstracts (2016) 86 P-P2-950

The Evolution of Thyroid Function after Hashimoto's Thyroiditis Presentation is Different in Initially Euthyroid Girls with or without Turner Syndrome

Malgorzata Wasniewskaa, Mariacarolina Salernob, Andrea Corriasc, Laura Mazzantid, Patrizia Matarazzoc, Domenico Coricaa, Tommaso Aversaa, Maria Francesca Messinaa, Filippo De Lucaa & Mariella Valenzisea


aDepartment of Human Pathology of Children and Adults, University of Messina, Messina, Italy; bPediatric Endocrinology Unit, Department of Translational Medical Sciences, University “Federico II” of Naples, Naples, Italy; cDepartment of Pediatrics, University of Turin, Turin, Italy; dDepartment of Pediatrics, S.Orsola-Malpighi University Hospital - University of Bologna, Bologna, Italy


Background: Hashimoto’s thyroiditis (HT) is the commonest autoimmune disorder in Turner syndrome (TS). Although there are in the pediatric literature many studies on the relationships between TS and HT, only few of them have specifically investigated whether the association with TS might be able to significantly affect the evolution over time of thyroid function in children and adolescents with HT, by conditioning a different thyroid status prognosis.

Objective and hypotheses: In the present multicenter study we have prospectively investigated, through a 5-yr follow-up, whether thyroid status prognosis of HT is different in euthyroid girls with TS than in euthyroid girls without TS.

Method: In 66 TS girls (aged between 4.5 and 17.9 yrs) and in 132 non-TS girls (aged between 4.5 and 17.9 yrs) with euthyroid HT and similar thyroid tests at HT diagnosis we followed up the evolution over time of thyroid status. At each annual examination TSH, FT4, thyroid peroxidase and thyroglobulin autoantibodies serum levels were measured.

Results: At the end of 5-yr follow-up TSH levels were higher and FT4 levels were lower in TS girls. Therefore, at the end of follow-up, TS girls exhibited lower prevalences of both euthyroidism and subclinical hypothyroidism, but higher prevalences of both overt hypothyroidism and hyperthyroidism, irrespective of karyotypes.

Conclusion: a) the association with TS is able to impair the long-term thyroid status prognosis in girls with HT; b) such effect is irrespective of thyroid function tests at HT diagnosis and is not necessarily linked with a specific karyotype.