Background: Thallassemia is a genetic disease with recessive autosomal pattern of inheritance which occurs as a result of disorders in hemoglobin structure clinicians assess endocrine function in patients with thallassemia in various intervals and distinguishing appropriate time for assessment can decrease the mentioned complications and promote their health.
Objective and hypotheses: We aimed to investigate the prevalence of hypothyroidism and the relation between thyroid hormones and ferritin in patients with thallassemia major referred to 17 shahrivar hospital.
Method: This is an analytic cross-sectional study which was conducted on records of patients with thallassemia major aged less than 20 years. All records of patients referred to blood and oncology clinic of 17 shahrivar hospital during January 2012December 2013 were assessed. Data were gathered by a form including age, sex, weight, height, body mass index, the initiation time of blood transfusion, thyroid test results, and three consecutive hemoglobin and ferritin levels. Mean ferritin and hemoglobin levels were assessed.
Results: Results showed significant linear correlation between first and mean ferritin with TSH (P<0.05) but no significant correlation was noted between levels of ferritin with T4 levels.
Conclusion: It seems that further investigations may be necessary in patients especially with thallassemia and compare it with normal population.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology