ESPE Abstracts (2018) 89 P-P2-124

Relationships of Dietary Intake and Sugar Rich Products Consumption with Hepatic Fat Content and Insulin Resistance among Children with Overweight/Obesity: The PREDIKID Study

Lide Aranazaa, Ignacio Diez-Lopezb,c, Maria Medranoa, Maddi Osesa, Inge Huybrechtsd, Fran B Ortegae & Idoia Labayena

aDepartment of Health Sciences, Public University of Navarra, Pamplona, Spain; bPeadiatric Endocrinology – HU Araba, Vitoria, Spain; cDepartament Peadiatric – Basque Country University – UPV/EHU, Vitoria, Spain; dNutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France; ePROmoting FITness and Health through physical activity research group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain

Pediatric non-alcoholic fatty liver disease (NAFLD) has increased in parallel with childhood obesity. Dietary habits, particularly products rich in sugars, may influence both hepatic fat content and insulin resistance. Hence, the aim of the current study was to examine the associations of the consumption of dietary foods (cereals, fruits and vegetables, meat and meat products, dairy products, fish and shellfish, total and added sugars) and composition (macronutrients and fiber), as well as the influence of the sugar-sweetened beverages (SSB) and dairy desserts and substitutes (DDS), on hepatic fat and insulin resistance in children with overweight/obesity. For such purpose, dietary intake (two non-consecutive 24h-recalls), hepatic fat content (magnetic resonance imaging) and insulin resistance (HOMA-IR) were assessed in 110 children (10.6±1.1 years old) with overweight/obesity. Linear regression analyses were used to examine the associations of dietary intake with hepatic fat content and HOMA-IR adjusted for potential confounders (sex, age, energy intake, maternal educational level, body fat percent or abdominal adiposity, and sugar intake). The results showed that both SSB consumption and sugar in SSB (β=0.202 and β=0.204, adjusted Ps<0.05), but not DDS or sugar in DDS or other dietary components, were positively associated with hepatic fat content regardless of potential confounders. In contrast, none of dietary variable was associated with insulin resistance. In conclusion, SSB consumption and its sugar content, but neither DDS nor sugar in DDS, may increase the likelihood of having NAFLD and therefore, nutritional intervention programs should be promoted so as to achieve healthy dietary habits since childhood.

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