ESPE Abstracts (2018) 89 P-P2-136

Dyslipidemia and Its Related Factors in Chinese Children and Adolescents with Turner Syndrome

Siqi Huang, Hongshan Chen, Minlian Du, Yanhong Li, Huamei Ma, Qiuli Chen, Jun Zhang & Song Guo

Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Turner syndrome is associated with insulin resistance, increased incidence of type II diabetes, and hypertension, all of which are cardiovascular risk factors. The purpose of this study was to evaluate the lipid profile of Chinese girls with untreated Turner syndrome, (aged 2 to 15 years; 50.9% 45,XO) and age-matched, normal girls. A total of 108 girls with Turner syndrome and 99 normal girls had lipid profile measurements, including cholesterol, triglycerides,high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. Older girls with Turner syndrome (>11 years, when the girls with Turner syndrome supposed to receive hormone replacement therapy) had increased triglycerides levels, higher incidence of hypertriglyceridemia, borderline-hypertriglyceridemia and borderline-hypercholesterolemia compared with control subjects. But there were no differences between TS patients who were less than 11 years old and age-matched control girls. TS patients of 45, XO karyotype had decreased triglycerides levels,increased high-density lipoprotein cholesterol levels and lower incidence of borderline-hypertriglyceridemia compared with those of other karyotypes. In the subjects with Turner syndrome but not the normal subjects, serum triglycerides positively related to waist circumference. We conclude that adolescent girls with untreated Turner syndrome have increased triglycerides levels,which may related to estrogen deficiency and chromosome karyotype.

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