Introduction: It has been suggested that adipokines found in breast milk and may be effective in early growth of infants.
Purpose: It was aimed to evaluate the relationship between total ghrelin (TGh) and nesfatin-1 levels in breast milk with anthropometric measurements in the first 4 months of life in infants with small for gestation age (SGA) showing fast growth pattern.
Method: A total of 20 SGA and 20 control infants with appropriate for gestational age (AGA) born between February 2017-August 2017 were involved in the study. Anthropometric measurements of infants have been performed at the 0-1st-4th months including head circumference (HC), chest circumference (CC) and mid-upper arm circumference (MAC). TGh and nesfatin-1 levels in the 1st and 4th months in the breast milk were studied with ELIZA method.
Results: The anthropometric measurements of SGA group in the birth and 1st month were determined significantly lower compared to those of AGA group (P<0.05). In the 4th month, TGh and nesfatin-1 values in breast milk in SGA infants were significantly lower compared to AGA infants (P<0.05). While there was no significant relation between 1st month nesfatin-1 levels in SGA group and 1st month antropometric measurements, it was found moderate negative correlation between birth weight, HC, MAC and 4th month nesfatin-1 levels and birth weight and CC (P<0.05).
Conclusion: TGh and nesfatin-1 levels in breast milk were established to show differences in SGA infants compared to AGA infants. In SGA group; determining of low breast milk TGh levels in the 4th month indicates that active Gh can be more effective in growth of these infants. On the other hand, decline in nesfatin-1 levels in the 4th month and negative correlation between nesfatin-1 and antropometric measurements show that nesfatin-1 can be a protective factor from obesity in these babies.
Keywords: Small for gestation age (SGA), appropriate for gestational age (AGA), breast milk, total ghrelin, nesfatin-1
27 - 29 Sep 2018
European Society for Paediatric Endocrinology