ESPE Abstracts (2018) 89 P-P2-150

ESPE2018 Poster Presentations Fat, Metabolism and Obesity P2 (58 abstracts)

Brown Adipose Tissue in Prepubertal Children: Associations with Sex and With the Sequence of Prenatal Growth Restraint and Postnatal Catch-up

Rita Malpique a, , José Miguel Gallego-Escuredo c, , Giorgia Sebastiani a, , Joan Villarroya c, , Abel López-Bermejo f , Francis de Zegher g , Francesc Villarroya c, & Lourdes Ibáñez a,

aPediatric Research Institute Sant Joan de Déu, University of Barcelona, Barcelona, Spain; bNetwork Biomedical Research Center of Diabetes and Associated Metabolic Disorders (CIBERDEM), Health Institute Carlos III, Madrid, Spain; cBiomedicine Institute, University of Barcelona, Barcelona, Spain; dNetwork Biomedical Research Center of Physiopathology of Obesity and Nutrition (CIBEROBN), Health Institute Carlos III, Madrid, Spain; eHospital de la Santa Creu i Sant Pau, Barcelona, Spain; fHospital Dr Josep Trueta & Girona Institute for Biomedical Research, Girona, Spain; gUniversity of Leuven, Leuven, Belgium

Background/objectives: Individuals born small-for-gestational age (SGA), especially those who experience postnatal catch-up growth, are at increased risk for developing endocrine-metabolic abnormalities before puberty. In adults, brown adipose tissue (BAT) has been associated with protection against metabolic disorders, such as obesity, type 2 diabetes and dyslipidaemia. Here, we assessed for the first time whether BAT activation differs between prepubertal children born SGA or appropriate-for-gestational age (AGA).

Subjects/methods: The study population consisted of 86 prepubertal children (41 AGA and 45 SGA; age (mean±S.E.M), 8.5±0.1 yr), recruited into two prospective longitudinal studies assessing endocrine-metabolic status and body composition in infancy and childhood. The temperature at the supraclavicular region (SCR) before and after a cold stimulus was measured by infrared thermal imaging, and the area of thermally active SCR (increase after cold challenge, ΔAreaSCR) was calculated as a surrogate index of BAT activation. The results were correlated with clinical, endocrine-metabolic and inflammation variables, and with visceral and hepatic adiposity (assessed by MRI).

Results: No differences in BAT activation index, as judged by ΔAreaSCR, were found between AGA and SGA children. However, girls showed higher baseline and post-cold induction AreaSCR than boys (both p≤0.01). An interaction between gender and birthweight subgroup was observed for BAT activation so that AGA girls increased significantly the thermally active SCR after cold challenge as compared to AGA boys; this increase did not occur in SGA girls vs SGA boys. Cold-induced ΔAreaSCR negatively correlated with HOMA-IR, us-CRP, liver volume and liver fat.

Conclusions: As compared to SGA girls, prepubertal girls born AGA appear to have a surplus of BAT vs their gender counterparts, that is negatively related to central (ectopic) adiposity. Long-term follow–up of these cohorts will disclose whether those differences are maintained through puberty and relate to pubertal timing, to subsequent changes in liver volume and hepatic fat, and to the development of obesity and metabolic and cardiovascular disorders.

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