ESPE Abstracts

Purpose: Reported changes in BMI in central precocious puberty (CPP) during and after gonadotropin-releasing hormone analog (GnRHa) treatment are inconsistent. We, therefore, investigated auxological parameters in GnRHa-treated girls with idiopathic CPP (ICPP) until attainment of near final height (NFH).

Methods: From the medical records of 59 ICPP girls who attained NFH after GnRHa therapy, auxological changes were compared between overweight (BMI ≥85 percentile) and normal-weight (BMI <85 percentile) groups. BMIs were changed into standard deviation scores (BMISDSs) for subject’s chronologic age (BMISDS-CA) and bone age (BMISDS-BA).

Results: The incidence of overweight including obesity was high at the start of therapy (35.6%). The predicted adult height (PAH) at start of therapy was significantly shorter than the mid-parental height (MPH), whereas PAH at end of therapy approached MPH, and NFH was greater than MPH. The height velocity (HV) in overweight group was higher during GnRHa therapy than that in normal-weight group, but those in the two groups were not different after therapy until NFH. Both BMISDS-CA and BMISDS-BA increased significantly during therapy, but, after therapy both BMISDSs decreased significantly until NFH. At NFH both BMISDSs were not different from those at baseline. In the normal-weight group, both BMISDSs increased during therapy and maintained that level until NFH. In overweight group, neither BMISDS changed during therapy, but there was a decrease after therapy until NFH.

Conclusion: The different patterns of BMISDS change during and after GnRHa therapy until NFH between the two groups were related to the different HV during GnRHa therapy.