ESPE Abstracts (2018) 89 P-P2-402

Association of Thyroid Stimulating Hormone and Free Thyroxine with Cardiometabolic Risk Factors in Euthyroid Korean children and Adolescents Aged 10-18 Years: The Korean National Health and Nutrition Examination Survey 2015

Jung Sub Lima, Young Suk Shimb & Eun Young Kimc

aDepartment of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea, Seoul, Republic of Korea; bDepartment of Pediatrics, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Republic of Korea; cDepartment of Pediatrics, Chosun University School of Medicine, Gwangju, Republic of Korea

Objective: The present study aimed to evaluate the association of free thyroxine (FT4) and TSH with insulin resistance indices in euthyroid Korean children and adolescents using nationally representative data.

Methods: A total of 259 children and adolescents were included in data from The Korean National Health and Nutrition Examination Survey 2015.

Results: TSH levels were significantly positively associated with HOMA-IR (β=0.106, P=0.039) whereas TSH levels were marginally associated with fasting insulin levels (β=0.085, P=0.098). FT4 levels were significantly negatively associated with HOMA-IR (β=−0.121, P=0.018) and fasting insulin (β=−0.128, P=0.012) after adjustment for confounding variables including gender, age, BMI SDS, SBP, DBP, T-C, TG, HDL-C, LDL-C, anti-TPO antibody, house income, smoking, alcohol intake, and physical activity. TSH (β=0.103, P=0.043) and FT4 (β=−0.119, P=0.020) were significantly associated with HOMA-IR whereas FT4 (β=−0.128, P=0.012) were significantly negatively associated with fasting insulin levels.

Conclusion: Our results suggest that free thyroxine (FT4) and TSH is related to insulin resistance in children and adolescents.

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