Objective: To explore the value of continuous hemodiafiltration in rescuing children with severe diabetic ketoacidosis.
Method: Two children with severe diabetic ketoacidosis were studied in regard to clinical manifestation, laboratory examination and treatment and of the relevant literature was reviewed.
Result: Case 1 was a girl of 13 years 5 months old, who was diagnosed as Type 1 diabetes mellitus, Diabetic ketoacidosis and Acute kidney injury (3 stage). After fluid infusing and blood sugar lowering with insulin, the metabolic acidosis could not be corrected. The girl was in a coma state with acute kidney injury. After Continuous hemodiafiltration (CHDF), both DKA and kidney injury was corrected. Case 2 was a girl of 2 months 8 days old, who was diagnosed as Neonatal diabetes mellitus, Diabetic ketoacidosis and Hyperglycemic Hyperosmolar State. The diabetic ketoacidosis was corrected and the hyperglycemia and hyperosmotic state was improved after CHDF.
Conclusion: CHDF is of great clinical value for saving patients with severe DKA, hyperglycemic hyperosmolar status, or renal failure. It is worthy of promoting.
27 - 29 Sep 2018
European Society for Paediatric Endocrinology