ESPE Abstracts (2019) 92 FC7.5

Is the 1-hour Post-Load Glucose Level by 75g Oral Glucose Tolerance Test a New Risk Factor in Predicting Atherosclerosis?

Suna Kilinç1, Tuna Demirtaş2, Zeynep Atay3


1University of Health Science, Bagcilar Training and Research Hospital, Department of Pediatric Endocrinology, Istanbul, Turkey. 2University of Health Science, Bagcilar Training and Research Hospital, Radiology, Istanbul, Turkey. 3Medipol University, Faculty of Medicine, Department of Pediatric Endocrinology, Istanbul, Turkey


Background and Objectives: Recent studies demonstrated that a 1-hour post-load plasma glucose (1-h PG) value of ≥155 mg/dL during an oral glucose tolerance test (OGTT) is a new risk factor for predicting atherosclerosis. Herein, we evaluated whether individuals with normal glucose tolerance (NGT), whose 1-h PG is ≥155mg/dl, or with impaired glucose tolerance (IGT) have an increased carotid intima–media thickness (CIMT), as compared with NGT individuals with 1-h PG <155 mg/dl.

Material and Methods: Obese adolescents at risk for prediabetes were administered a 75g OGTT. CIMT was measured in all patients on the same day with OGTT. Individuals with prediabetes were identified according to fasting plasma glucose concentration and/or HbA1C (5.7-6.4%). Patients with diabetes were excluded from the study. Subsequently, subjects were divided in 3 groups: that have NGT with a 1-h PG < 155 mg/dl, have NGT with a 1-h PG ≥155 mg/dl, and have IGT.

Results: The study included 171 obese adolescents with prediabetes (74 males, 97 females; mean age: 13.5 ± 1.8 years). Seventy-three patients were NGT with a 1-h PG < 155 mg/dl, 29 patients were NGT with a 1-h PG ≥155 mg/dl and 69 patients were IGT. No statistically significant difference was found between the groups in terms of age, weight, height and BMI (P> 0.05). As compared with NGT individuals with a 1-h PG <155 mg/dl, NGT individuals with a 1-h PG ≥155mg/dl exhibited higher CIMT (0.75±0.15 mm vs. 0.68±0.15 mm; P=0.025). No significant differences were observed in CIMT between IGT and NGT subjects with a 1-h PG ≥155 mg/dl (0.75±0.18 mm vs 0.75±0.15 mm; P>0.05). Of the three glycemic parameters, 1-h and 2-h PG, but not fasting glucose, were significantly correlated with CIMT.

Conclusion: These data suggest that a cutoff point of 155 mg/dl for the 1-h PG during OGTT may be a useful tool to identify a subset of individuals at higher risk of developing cardiovascular disease.

Key words: Prediabetes, obesity, 1-hour post-load plasma glucose, intima-media thickness

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