hrp0092fc7.5 | Diabetes and Insulin Session 2 | ESPE2019

Is the 1-hour Post-Load Glucose Level by 75g Oral Glucose Tolerance Test a New Risk Factor in Predicting Atherosclerosis?

Kilinç Suna , Demirtaş Tuna , Atay Zeynep

Background and Objectives: Recent studies demonstrated that a 1-hour post-load plasma glucose (1-h PG) value of ≥155 mg/dL during an oral glucose tolerance test (OGTT) is a new risk factor for predicting atherosclerosis. Herein, we evaluated whether individuals with normal glucose tolerance (NGT), whose 1-h PG is ≥155mg/dl, or with impaired glucose tolerance (IGT) have an increased carotid intima–media thickness (CIMT), as compared with NGT in...

hrp0092p1-60 | Fat, Metabolism and Obesity | ESPE2019

The Effect of Improved Metabolic Risk Factors and Metformin Therapy on Circulating Hepatokines in Obese, Insulin-Resistant Adolescents

Kilinç Suna , Kirankaya Aysegül , Atay Zeynep

Introduction: The molecular mechanisms underlying insulin resistance (IR) is complex and has not been fully elucidated yet. The experimental studies point out the role of liver-derived proteins, called hepatokines.Aims: To compare metabolic parameters and hepatokines levels in obese adolescents and healthy controls and to assess the effect of metformin therapy on plasma hepatokines levels in obese, insulin-resistant adol...

hrp0092p1-208 | Fetal, Neonatal Endocrinology and Metabolism (to include Hypoglycaemia) (1) | ESPE2019

Transient Gonadal Activation and Infant Growth Velocity

Kilinç Suna , Hamilçikan Sahin , Atay Enver , Atay Zeynep

Background: Hypothalamic-pituitary-gonadal axis is activated during the first 6 months of life, called as mini-puberty in which reproductive hormone levels may reach to adult levels. Although, our understanding of the pathophysiology of sex steroids interaction with growth in puberty is increasing, very little is known about the relationship between sex steroids and growth at this period of life.Material and Methods: 142...

hrp0092p1-294 | Thyroid (1) | ESPE2019

Effect of serum TSH level on ovarian volume in prepubertal girls with subclinical hypothyroidism

Yigit Özgül , Sert Tugba , Ekinci Deniz , Kirankaya Aysegül , Kilinç Suna

Background and Objectives: Enlargement and cystic changes in ovaries of patients with longstanding overt hypothyroidism has been observed in numerous case reports. But there is limited data about the effect of subclinical hypothyroidism (SH) on ovarian volume and ovarian cyst formation. We evaluated the relationship between serum thyroid stimulating hormone (TSH) level and ovarian volume and sonographic appearance in prepubertal girls with SH.<p class="abs...

hrp0092p1-351 | Fat, Metabolism and Obesity (2) | ESPE2019

Congenital Generalized Lipodystrophy Type 4 - New Mutation in the CAVIN1 Gene

Döger Esra , Sezer Abdullah , Ugurlu Aylin Kilinç , Akbas Emine Demet , Perçin Ferda , Bideci Aysun , Çamurdan Orhun , Cinaz Peyami

Introduction: Congenital generalized lipodystrophies (CGL); autosomal recessive disorders characterized by dyslipidemia and almost complete absence of body fat associated with insulin resistance. It develops due to mutations in AGPAT2, BSCL2, CAV1, PTRF, PCYT1A and PPAR, genes.CGL type 4 results from PTRF-CAVIN gene mutation. Unlike classical CGL, myopathy, flat and skeletal muscle hypertrophy, heart rhythm disorders (sudden death) and skeletal abnormalities a...

hrp0092p2-44 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Cinacalcet Experience in Hypercalcemia Due to CaSR Mutation

Döger Esra , Akbas Emine Demet , Kilinç Ugurlu Aylin , Küpçü Zekiye , Bideci Aysun , Çamurdan Orhun , Cinaz Peyami

Introduction: Heterozygous inactivating mutations of the CaSR gene (CaSR) generally result in mild, asymptomatic hypercalcemia in the familial hypocalcuric hypercalcemia syndrome. Homozygous inactivating CaSR mutations end up with neonatal severe hyperparathyroidism. Calcimimetics are drugs that interact with the transmembrane part of CaSR and make the receptor more sensitive to calcium. Cinacalcet, a type II calcimimetic, suppresses PTH levels and increases r...

hrp0092p2-103 | Diabetes and Insulin | ESPE2019

Evaluation of the Association of Glutamic Acid Decarboxylase Antibody and Limbic Encephalitis in Children with Type 1 Diabetes Mellitus

Ugurlu Aylin Kilinç , Bideci Aysun , Arhan Ebru , Döger Esra , Serdaroglu Ayse , Tekin Orgun Leman , Soysal Acar Azime Sebnem , Çamurdan Orhun , Cinaz Peyami , Gücüyener Kivilcim

Glutamic acid decarboxylase (GAD) is the enzyme that catalyzes the conversion of L-glutamat into GABA, one of the classical neurotransmitters with neuroinhibitory function. GAD is present in GABAergic neurons and in pancreatic beta cells. It is remarkable that Anti-GAD antibody(Anti-GADab) can have different disease manifestations, i.e., Type 1 diabetes mellitus (T1DM), Stiff-Person Syndrome, limbic encephalitis (LE), epilepsy. Cooccurence of T1DM and LE is reported in the lit...