ESPE2019 Poster Category 1 Diabetes and Insulin (2) (26 abstracts)
Abdominal Fat Distribution Assessed by Abdominal CT Scan in Adolescents with Type 2 Diabetes Mellitus
Yuriko Abe 1 , Tatsuhiko Urakami 1 , Mitsuhiko Hara 2,3 , Kei Yoshida 1 , Yusuke Mine 1 , Masako Aoki 1 , Junichi Suzuki 1 , Emiko Saito 2,3 , Fujihiko Iwata 1 , Tomoo Okada 4,1 & Ichiro Morioka 1
1Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan. 2Department of Pediatrics, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan. 3Department of Human Nutrition, Tokyo Kasei Gakuin University, Tokyo, Japan. 4Department of Nutrition and Life Science, Kanagawa Institute of Technology, Atsugi, Japan
Background: Abdominal fat distributions are reportedly strongly associated with metabolic risks in type 2 diabetes mellitus. However, research on fat distribution in adolescents with type 2 diabetes mellitus has been limited.
Aim: To investigate fat distribution characteristics in adolescents with type 2 diabetes mellitus for comparison to those with simple obesity in Japan.
Design/Methods: Sixty-one adolescents 10 to 15 years of age with simple obesity or type 2 diabetes mellitus, who visited our outpatient clinics between 2002 and 2018, were enrolled in this study with ethics approval. Simple obesity was defined as a BMI ≥95%ile without. Serum lipids, ALT and HbA1c were measured without fasting. Visceral fat area (VFA) and subcutaneous fat area (SFA) were investigated using umbilical level CT scans. Subjects were classified into 2 subgroups: simple obesity group (n=38) or the type 2 diabetes mellitus group (n=23).
Results: Comparisons between the 2 groups are shown in Table 1. VFA and the ratio of VFA to SFA (V/S ratio) were significantly higher in the type 2 diabetes mellitus group than in the simple obesity group (VFA (cm2): 74 vs 89.2, P=0.0400, V/S ratio: 0.2 vs 0.32, P<0.0001). SFA was significantly lower in the type 2 diabetes mellitus group than in the simple obesity group (SFA (cm2) 357 vs 260, P= 0.0076). VFA and SFA correlated with systolic blood pressure (P=0.0009, 0.0099, respectively), ALT (P=0.0486, 0.0486, respectively), total cholesterol (P=0.0178, 0.0032, respectively), and non-HDL cholesterol (P=0.0065, 0.0010, respectively) in the type 2 diabetes mellitus group.
Conclusion: The abdominal fat distributions in type 2 diabetes mellitus differ from those in simple obesity, in adolescent subjects. VFA and SFA correlated with the metabolic parameters in adolescents with type 2 diabetes mellitus.
| Simple obesity (n=38) | Type 2 diabetes mellitus (n=23) | p-value | |
| Age (years) | 12 (10-15) | 12 (10-15) | 0.6794 |
| Sex (%Male) | 52 | 52 | 0.9723 |
| BMI %tile | 99.1 (95.6-99.9) | 97.9 (88.1-99.9) | 0.1348 |
| Systolic blood pressure (mmHg) | 110 (93-146) | 116 (101-149) | 0.0692 |
| Diastolic blood pressure (mmHg) | 63 (46-78) | 67 (54-89) | 0.0451* |
| ALT (U/L) | 32 (10-282) | 50.5 (13-251) | 0.0426* |
| Total cholesterol (mg/dL) | 163 (126-253) | 192.5 (125-230) | 0.0863 |
| HDL cholesterol (mg/dL) | 47.5 (30-76) | 44 (26-49) | 0.0267* |
| non-HDL cholesterol (mg/dL) | 123 (73-207) | 146 (88-187) | 0.0344* |
| HbA1c (%) | 5.6 (5.3-6.1) | 8.3 (6.1-14.5) | <0.0001* |
| VFA (cm2) | 74 (25-138) | 89.2 (33-206) | 0.0400* |
| SFA (cm2) | 357 (198-619) | 260 (94-605) | 0.0076* |
| V/S ratio | 0.20 (0.09-0.38) | 0.32 (0.20-0.76) | <0.0001* |
| * P<0.05 | |||
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