Introduction: Preclinical models demonstrated that Angiopoietin-like protein 4 (ANGPTL-4) regulates lipid metabolism and affects energy homeostasis. However, no data exist regarding its involvement in childhood and adolescence, periods of life with important metabolic changes.
Objectives: We aimed to investigate circulating levels of ANGPTL-4 in children and adolescents and its relationship with gender, puberty and obesity.
Material and Methods: Plasma ANGPTL-4 levels were analysed in 150 Caucasian children (72) and adolescents (78). The sample was classified as obese (percentile ≥ 95th; n = 77) and normal-weight (n = 73) by using the standard definition from Cole et al. The concentration of ANGPTL-4 was measured using an ELISA kit (Human ANGPTL4 ELISA kit SK00309-01; Aviscera Bioscience) and statistical analyses were performed using the SPSS software.
Results: Girls and boys showed similar concentrations in plasma levels of ANGPTL-4. The puberty did not modify the ANGPTL-4 circulating levels. However, ANGPTL-4 was significantly reduced in children and adolescents with obesity compared to lean participants. This reduction was independent of the gender and sexual maturation. Moreover, ANGPTL-4 was negatively correlated with BMI, body weight and waist circumference.
Conclusion: This study reveals that ANGPTL-4 levels are deregulated in children and adolescents with obesity independently of the gender and puberty.
Acknowledgments: CIBERobn, ISCIII (PI18/00998, PI15/01272, PI11/02042, PI16/01301, PI16/00871), FEDER, Fundación Mutua Madrileña.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology