Background: In adult studies, serum uric acid level (SUA) has been shown to be associated with cardiometabolic anomalies of metabolic syndrome such as insulin resistance, hypertension, increased carotid intima thickness, and hyperuricemia is considered as an independent risk factor for atherosclerosis and cardiovascular disease. Early cardiovascular changes in obese children and studies on the relationship between metabolic syndrome and hyperuricemia are quite limited. In our study, it was aimed to evaluate the relationship between SUA level and obesity comorbidities in obese children and adolescents and cardiometabolic risk.
Material-Methods: The records of 144 obese patients aged 10-18 years were evaluated retrospectively. According to age and sex, SUA level was <95 percentile group1 and SUA level was ≥95 percentile group 2. Body mass index (BMI), hypertension, lipid profile, insulin resistance, serum transaminases, hepatosteatosis, ambulatory blood pressure measurements (ABPM), and left ventricular hypertrophy based on the measurement of left ventricular mass in echocardiography were compared between the two groups.
Results: In group 2, BMI SDS, serum triglyceride, AST, ALT levels and hepatosteatosis were significantly higher, whereas HDL level was significantly lower. In OGTT, 60, 90 and 120.min glucose levels and 120 min insulin levels were significantly higher in Group2. No differences were found between groups HbA1C and HOMA-IR. When the presence of hypertension was evaluated; both office and ABPM measurements were significantly higher in group 2. Left ventricular hypertrophy was found in 38. 2 % of the cases in group 2 and the mean left ventricular mass index was significantly higher with 38.05 ± 11.39g /m 2.7.
Conclusions: The identification of children with a high risk of cardiometabolic is extremely important for the prevention of complications related to childhood obesity. We suggest that serum uric acid levels may be an early marker of obesity comorbidity and cardiovascular dysfunction in obese children and adolescents.
Keywords: Childhood obesity, uric acid, cardiometabolic risk
19 - 21 Sep 2019
European Society for Paediatric Endocrinology