Objective: evaluate insulin resistance (IR) in children and adolescents with exogen-constitutional obesity (ECO) depending on the stage of sexual development.
Materials and research methods: 100 children and adolescents with ECO of the UzBek population from 6 to 16 years were observed (mean age 11.7 ± 0.25 years). The control group consisted of 71 healthy children of the appropriate age (mean age 11.1 ± 0.33 years).
All children and adolescents were evaluated: anthropometric indicators. The criteria for overweight and obesity in children were determined according to the percentile BMI tables (WHO 2007). The level of fasting immunoreactive insulin (IRI) using the RIA method. IR indicators were calculated using the following HOMA formulas (HOMA-IR Index Homeostasis Model Assessment).
Results and Discussion:It is established that the analysis of the fasting IRI level in the control group did not reveal a significant difference from the stage of sexual development and gender. Boys and girls with ECO, regardless of the sexual development stage, the indicator of fasting IRI was above control.
The HOMA-IR index is significantly higher in patients with ECO than in healthy children, regardless of gender and sexual development stage. IR (NOMA values> 97 per.) were detected in IVF, respectively, in 44.4% and 18.2% of boys and girls with a stage of sexual development 1 according to Tanner. In adolescents (65.5% - boys and 40.9% - girls), cases of HOMA> 97 peppers were also detected in the initial puberty stage. 68.8% of boys and 61.5% of girls with 4-5 stage according to Tanner had an index BUT-MA> 97 per. It should be noted that such values were more common in boys than in girls at all stages of sexual development.
Conclusions: Thus, the conducted studies that HOMA values> 97 per. were more common in boys than in girls at all stages of sexual development. In children with obesity, dysmetabolic disorders associated with IR, matters as the main component of the metabolic syndrome. The study of glycemia and IRI on an empty stomach with the calculation of HOMA-IR should be mandatory for children with progressive obesity.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology