Objective: Allostatic load (AL) refers to the physiological response that occurs in chronic stress burden, Excessive weight gain is an important source of physiological stress promoting chronic low-inflammation state detrimental for health. We estimated AL score among a pediatric population, in order to define a correlation between cumulative biological dysregulation and excess weight.
Methods: We enrolled 164 children and adolescents (11.89 ± 3.89). According to body mass index (BMI) threshold, the subjects were classified as normal weight BMI<75th percentile; overweight BMI 75-95th percentile; obese BMI>95th percentile. Data based on 16 biomarkers were used to create the AL score. A dichotomous outcome of high AL, was defined for those who had >4 dysregulated components.
Results: High AL was noted in 88/164 subjects (53.65%), without significant difference in sex distribution (P =0.07) and pubertal status (P=0.10).
The subjects with high AL had a significantly higher BMI (P<0.001), WC and WC/HtR (P<0.001), triglycerides (P=0.002), fasting blood glucose (P=0.03), insulin resistance (P<0.001), systolic (P<0.001) and diastolic blood pressure (P=0.001), GGT (P=0.01), PCR (P=0.01) and calprotectin (P<0.01) as well as lower HDL cholesterol (P=0.002) than subjects with low AL.
A significant correlation between high AL and overweight/obesity was reported (P<0.001). The rate of the cumulative biological dysregulation increased progressively with the increase in BMI categories (P< 0.001).
Conclusions: high AL was associated with excess weight. AL may be considered a significant contributor correlated to increased morbidity in children with overweight/obesity.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology