Vitamin D deficiency in obese children

Hanna Mikhno; Anzhalika Solntsava

Objective: determination of changes in metabolic status and vitamin D concentrations in obese children.

Methods: We examined 221 children in the University Hospital (Minsk) from 2019 to 2021 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO) - 159 patients (98 boys(B)/61 girls(G)) (BMI more than 99th percentile for sex and age) (BMI 33.04±4.67 kg/m², age 13.17±2.42 years); group 2 - 62 patients (B/G=31/31) with alimentary obesity (AO) (BMI-95-99th percentile for sex and age) (BMI 27.60±2.06 kg/m², age 13.43±2.27 years). The control group (C) consisted of 60 patients (B/G=30/30) with normal body weight (BMI 19.86±2.24 kg/m², age 13.32±2.30 years).

Results: In boys and girls with obesity higher concentrations of insulin were detected relative to the control group (АО (G 16.36 (9.90–19.20) µU/ml; B 17.07 (8.40–20.00) µU/ml) and МО (G 21.06 (12.60–24.50) µU/ml; B 20.79 (12.75–25.40) µU/ml); С (G 8.35 (5.90–11.30) µU/ml ; B 9.83 (7.90-11.40) µU/ml) (G U_АО-К=228.00; р=0.0001; U_МО-К=276.00; р=0.0001; B U_АО-К=493.50; р=0.0001; U_МО-К=641.00; р=0.0001)). Insulin resistance index level (HOMA-IR) in patients with О (G 3.23 (1.97–3.94); B 3.49 (1.75–4.27)) and МО (G 4.14 (2.37–5.32); B 4.31 (2.55–5.46)) was higher than in the control (G 1.60 (0.99–2.18); B 1.89 (1.53–2.30)) (G U_АО-К=219.00; р=0.0001; U_МО-К=304.00; р=0.0001; B U_АО-К=1050.50; р=0.0001; U_МО-К=592.50; р=0.0001). In patient of the study group a significant decrease in the level of vitamin D (G АО 25.90 (22.53–30.58) vs 39.36 (32.00–45.94) ng/ml; U=67.00; р=0.0001; G МО 20.18 (15.22–25.60) vs 39.36 (32.00–45.94) ng/ml; U=36.50; р=0.0001; B АО 27.57 (24.03–31.78) vs 36.12 (30.77–41.69) ng/ml; U=161.50; р=0.0001; B МО 23.01 (17.94–28.89) vs 36.12 (30.77–41.69) ng/ml; U=327.00; р=0.0001).

Conclusion: Children with obesity have a significant decrease in the concentration of vitamin D.

ESPE Abstracts

P2-194