Background: Data on female fertility, pregnancy, and outcome of offspring after childhood-onset craniopharyngioma (CP) are rare.
Study design: Observational study on pregnancy rate and outcome of offspring after CP in postpubertal, female patients recruited in KRANIOPHARYNGEOM 2000/2007 since 2000.
Results: 451 CP patients (223 female) have been recruited. 269 CP patients (133 female) were postpubertal at study. Six of 133 female CP patients (4.5%) with a median age of 14.9 years at CP diagnosis had 9 pregnancies, giving birth to 10 newborns. Three patients achieved complete surgical resections. No patient underwent postoperative irradiation. Five natural pregnancies occurred in 3 CP patients without pituitary deficiencies. Four pregnancies were achieved in 3 CP with hypopituitarism under assisted reproductive techniques (ART) (after median 4.5 cycles, range: 36 cycles). Median maternal age at pregnancy was 30 years (range: 2241 years). Six babies (60%) were delivered by caesarean section. Median gestational age at delivery was 38 weeks (range: 3443 weeks); median birth weight was 2,920 grams (range: 2,2703,520 grams), the rate of preterm delivery was 33%. Enlargements of CP cysts occurred in 2 women during pregnancy. Other severe complications during pregnancy, delivery and postnatal period were not observed.
Conclusions: Pregnancies after CP are rare and achieved in 45% after ART. Close monitoring by an experienced reproductive physician is necessary. Due to a potentially increased risk for cystic enlargement, MRI of cystic CP is recommended during pregnancy. Severe perinatal complications, birth defects, and postnatal morbidity of mothers and offspring were not observed.
22 Sep 2021 - 26 Sep 2021