ESPE Abstracts

Childhood obesity (CO) is an important risk factor for the development of many chronic metabolic diseases in adulthood. Sleep patterns are known to affect leptin and ghrelin levels in the body. Recent studies using Functional Magnetic Resonance Imaging (fMRI) have shown that insufficient sleep time leads to unhealthy eating behaviors in the brain. The aim of this study is to investigate the association between sleep time in childhood and obesity. Consistent with this association, the effects of early sleep time on insulin resistance and lipid profile are the first questions that arise. Accordingly, we are investigating whether early sleep prevents obesity." The study included 115 obese children with a BMI > 95th percentile. Biochemical (fasting serum glucose, lipid profile) and hormonal (fasting insulin) panels were queried after detailed history, anthropometric assessment, and physical examination in 115 cases presenting to our Pediatric Endocrinology clinic. Clinical assessments included insulin resistance measured by HOMA-IR ([fasting blood glucose (mmol/l) x fasting serum insulin (mIU/L)]/22.5). We also measured the triglyceride and HDL levels of each patient. We also divided our cases into two groups: sleepers between 21: 00-21: 30 and late sleepers. The mean weight and BMI SDS were 72.31 kg and 2.98, respectively, and the mean triglyceride and HDL levels of those who slept between 21: 00 and 21: 30 were 84.13 mg/dl and 49.67 mg/dl, respectively. Moreover, the mean triglyceride and HDL values of the patients who slept after 21: 30 were 106.31 mg /dl and 44.34 mg/dl, respectively. Accordingly, the TG levels of patients who slept between 21: 00-21: 30 were lower than those who slept later (p = 0.067). In contrast, HDL levels of patients who slept between 21: 00-21: 30 were significantly higher than those who slept later (p = 0.019). While the mean HOMA-IR index of sleepers between 21: 00-21: 30 was 4.78, the mean HOMA-IR index of late sleepers was 5.21 (p = 0.527). The analysis shows that patients who sleep earlier (21: 00-21: 30) have lower HOMA-IR index and lower triglycerides and higher HDL levels. The results further show that early sleep reduces insulin resistance and prevents dyslipidemia. In this study, we demonstrate that early sleep reduces insulin resistance and prevents dyslipidemia. Demonstration of this mechanism may be the goal of future studies in this regard.