ESPE2021 ePoster Category 2 Fat, metabolism and obesity (59 abstracts)
Impact of weight loss on gonadic function in overweight and obese boys
Solène Rérat 1 , Régis Coutant 1 , Marion Beaumesnil 2 , Marie-clémence L’hours 3 , Natacha Bouhours-Nouet 1 , Aurélie Donzeau 1 , Stéphanie Rouleau 1 , Lucie Levaillant 1 , Fabienne Emeriau 1 , Valérie Moal 1 , Florence Boux de casson 1 & Jessica Amsellem-Jager 1
1Angers University Hospital, Angers, France; 2Pediatric Rehabilitation Center, Angers, France; 3Children’s Hospital, Lorient, France
Introduction: In obese boys, alteration of Sertoli and Leydig cell functions have been described, but potential reversibility of these alterations after weight loss during childhood has not been fully evaluated.
Objective: Evaluate the impact of weight loss on gonadic function in obese boys.
Setting: Monocentric study in the Pediatric Endocrinology Unit of Angers University Hospital ant its follow-up and rehabilitation care.
Methods: Thirty-four obese boys aged 10 to 18 participated between 2012 and 2020 to a 12-weeks therapeutic educational program. At baseline and at week 12, all underwent physical examination, DEXA for body composition, and measurements of FSH, LH, AMH, inhibin B, testosterone, estradiol, fasting insulin, and glucose.
Results: Weight, Body Mass Index (BMI), percentage of fat mass, fasting insulin, and Homeostasis model assessment of insulin resistance (HOMA-IR) decreased significantly at week 12 (P < .01). Median testosterone levels increased significantly after weight loss (P = .001), and this increase correlates with the amount of fat mass loss (r = -0.39, P < .05). Median inhibin B, AMH, FSH, LH and estradiol levels were not statistically different after weight loss.
Conclusion: Alteration of Leydig cell function may be reversible after weight loss in obese children, while no change was found in Sertoli cell function. Increase in testosterone levels may be linked to fat mass loss.
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