ESPE2021 ePoster Category 2 Fat, metabolism and obesity (59 abstracts)
HOMA-IR in obese children with BMI ≥2.5SDS, but not <2.5SDS, differ significantly from normal weight children
Sofia Leka-Emiri 1 , Maria Dikou 1 , Catherine Evangelopoulou 1 , Maria Kafetzi 2 , Vasilios Petrou 1 , Elpis Vlachopapadopoulou 1 & Stefanos Michalacos 1
1Division of Endocrinology-Growth and Development, “P&A Kyriakou” Children’s Hospital, Athens, Greece; 2Division of Biochemistry-Hormonology, “P&A Kyriakou” Children’s, Athens, Greece
Objective: Compare HOMA-IR between obese and normal weight children.
Methods: 292 children (156 females), BMI (≥0SD), Tanner stage 1/>2: 163/129, divided in four groups (Group 1: 0SD<BMI<2SD, Group 2: 2SD≤BMI<2.25SD, Group 3: 2.25SD≤BMI<2.5SD, Group 4: BMI≥2.5SD) were analyzed retrospectively from the medical records. Age, sex, fasting blood glucose and insulin as well as the homeostasis model assessment of insulin resistance (HOMA-IR) [(fasting glucose- mmol/lt×fasting insulin mIU/l)/22.5] were recorded and insulin resistance was defined as HOMA-IR≥ 3.4. One-Way and Two-Way Analysis of variance (ANOVA), P < 0.05, were calculated among groups using the SPSS statistics program.
Results: Mean age was 9.5 yrs (SD, 3.07), BMI: 2.28 (SD, 0.59), HOMA-IR: 3.88 (SD, 3.6), fasting glucose: 87.3 (SD, 8.3) mg/dl, fasting insulin: 17.9 (SD, 16) mIU/lt. Clinical and laboratory characteristics are summarized in table 1. HOMA-IR was significantly higher in group 4 only as opposed to group 1 (p: 0.02) but not group 2 or 3. Prepubertal boys in groups 2, 3, 4 and overall had higher HOMA-IR as opposed to girls (4.1/3.5, boys/girls), but in puberty this finding was reversed (3.6/4.4 boys/girls). However, there was no statistically significant difference among groups in relation to sex or puberty.
| Group 1 (n = 55) | Group 2 (n = 78) | Group 3 (n = 70) | Group 4 (n = 89) | p | |
| Age (yrs) | 10.9 (2.4) | 9.7 (2.2) | 9.5 (2.8) | 7.6 (3.6) | * |
| Sex (boys/girls) | 20/35 | 37/41 | 32/38 | 47/42 | |
| Tanner stage Ι/ΙΙ-ΙV | 20/35 | 47/31 | 36/34 | 60/29 | * |
| BMI z-score | 1.7 (0.27) | 2.1 (0.06) | 2.4 (0.08) | 2.9 (0.65) | * |
| ΗΟΜΑ IR | 3.1 (1.0) | 3.6 (3.0) | 3.9 (2.7) | 4.6 (5.1) | * |
| Fasting Glucose (mg/dl) | 89(8.6) | 87 (8.3) | 87 (7.8) | 86 (8.2) | * |
| Fasting Insulin (mU/lt) | 14 (8) | 17 (14) | 18 (11) | 21 (23) | * |
Conclusion: Obese children with BMI ≥2.5SDS, but not BMI<2.5SDS, present significantly higher HOMA-IR as opposed to normal weight children, irrespectively of sex or Tanner stage.
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