ESPE Abstracts (2021) 94 P2-206

Fat, metabolism and obesity

HOMA-IR in obese children with BMI ≥2.5SDS, but not <2.5SDS, differ significantly from normal weight children

Sofia Leka-Emiri1, Maria Dikou1, Catherine Evangelopoulou1, Maria Kafetzi2, Vasilios Petrou1, Elpis Vlachopapadopoulou1 & Stefanos Michalacos1


1Division of Endocrinology-Growth and Development, “P&A Kyriakou” Children’s Hospital, Athens, Greece; 2Division of Biochemistry-Hormonology, “P&A Kyriakou” Children’s, Athens, Greece

Objective: Compare HOMA-IR between obese and normal weight children.

Methods: 292 children (156 females), BMI (≥0SD), Tanner stage 1/>2: 163/129, divided in four groups (Group 1: 0SD<BMI<2SD, Group 2: 2SD≤BMI<2.25SD, Group 3: 2.25SD≤BMI<2.5SD, Group 4: BMI≥2.5SD) were analyzed retrospectively from the medical records. Age, sex, fasting blood glucose and insulin as well as the homeostasis model assessment of insulin resistance (HOMA-IR) [(fasting glucose- mmol/lt×fasting insulin mIU/l)/22.5] were recorded and insulin resistance was defined as HOMA-IR≥ 3.4. One-Way and Two-Way Analysis of variance (ANOVA), P < 0.05, were calculated among groups using the SPSS statistics program.

Results: Mean age was 9.5 yrs (SD, 3.07), BMI: 2.28 (SD, 0.59), HOMA-IR: 3.88 (SD, 3.6), fasting glucose: 87.3 (SD, 8.3) mg/dl, fasting insulin: 17.9 (SD, 16) mIU/lt. Clinical and laboratory characteristics are summarized in table 1. HOMA-IR was significantly higher in group 4 only as opposed to group 1 (p: 0.02) but not group 2 or 3. Prepubertal boys in groups 2, 3, 4 and overall had higher HOMA-IR as opposed to girls (4.1/3.5, boys/girls), but in puberty this finding was reversed (3.6/4.4 boys/girls). However, there was no statistically significant difference among groups in relation to sex or puberty.

Table 1 Clinical and laboratory characteristics, Mean (SD).
Group 1 (n = 55)Group 2 (n = 78)Group 3 (n = 70)Group 4 (n = 89)p
Age (yrs)10.9 (2.4)9.7 (2.2)9.5 (2.8)7.6 (3.6)*
Sex (boys/girls)20/3537/4132/3847/42
Tanner stage Ι/ΙΙ-ΙV20/3547/3136/3460/29*
BMI z-score1.7 (0.27)2.1 (0.06)2.4 (0.08)2.9 (0.65)*
ΗΟΜΑ IR< 3.4≥ 3.43.1 (1.0)69%31%3.6 (3.0)62%38%3.9 (2.7)52%48%4.6 (5.1)52%48%*
Fasting Glucose (mg/dl)89(8.6)87 (8.3)87 (7.8)86 (8.2)*
Fasting Insulin (mU/lt)14 (8)17 (14)18 (11)21 (23)*

Conclusion: Obese children with BMI ≥2.5SDS, but not BMI<2.5SDS, present significantly higher HOMA-IR as opposed to normal weight children, irrespectively of sex or Tanner stage.

Volume 94

59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

European Society for Paediatric Endocrinology 

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