ESPE2021 ePoster Category 2 Fat, metabolism and obesity (59 abstracts)
Absence of dyslipidemia in obese children with BMI ≥2.5SDS and similar lipidemic profile to those with BMI <2.5SDS or normal weight
Sofia Leka-Emiri 1 , Maria Dikou 1 , Catherine Evangelopoulou 1 , Maria Kafetzi 2 , Vasilios Petrou 1 , Elpis Vlachopapadopoulou 1 & Stefanos Michalacos 1
1Division of Endocrinology-Growth and Development, “P&A Kyriakou” Children’s Hospital, Athens, Greece; 2Division of Biochemistry-Hormonology, “P&A Kyriakou” Children’s Hospital, Athens, Greece
Objective: Compare triglycerides, total cholesterol, HDL and LDL levels between obese and normal weight children.
Methods: 547 children (286 females) with BMI (≥0SD) were divided in four groups (Group 1: 0SD<BMI<2SD, Group 2: 2SD≤BMI<2.25SD, Group 3: 2.25SD≤BMI<2.5SD, Group 4: BMI≥2.5SD) and analyzed retrospectively from the medical records. Age, sex, BMI z-score, triglycerides, total cholesterol, HDL and LDL (mg/dl) levels were recorded. One-Way Analysis of variance (ANOVA) and x2 test (P < 0.05) were calculated among groups using the SPSS statistics programme.
Results: Mean age was 9.5yrs (SD, 3.07), BMI: 2.28(SD, 0.59), Total cholesterol: 166.9 (SD, 32.7), triglycerides: 81.5 (SD, 46.2), HDL: 52.3 (SD, 13.0), LDL: 99.5 (SD, 27.3). Clinical and laboratory characteristics are summarized in table 1. There was neither statistically significant difference in the sex distribution nor statistically significant difference in the lipidemic profile among the four groups. Obese children were more often prepubertal as opposed to normal weight children (P < 0.05).
| Group 1 (n = 157) | Group 2 (n = 130) | Group 3 (n = 124) | Group 4 (n = 136) | p | |
| Age (yrs) | 10.9 (2.4) | 9.7 (2.2) | 9.5 (2.8) | 7.6 (3.6) | * |
| Sex (males/females) | 67/90 | 63/67 | 60/64 | 71/65 | NS |
| Tanner 1/>2 | 43%/57% | 65%/35% | 64%/36% | 76%/24% | ** |
| BMI z-score | 1.7 (0.27) | 2.1 (0.06) | 2.4 (0.08) | 2.9 (0.65) | * |
| Total cholesterol (mg/dl) <200 >=200 | 164.5 (34.1) 86% 14% | 171 (35) 79% 21% | 160.7 (28.9) 89% 11% | 169.5 (31.7) 86% 14% | NS |
| Triglycerides (mg/dl) <100 >=100 | 75.9 (39.4) 82% 18% | 85.8 (44.3) 73% | 81.7 (59.1) 76% 24% | 83.6 (41.3) 76% 24% | NS |
| HDL(mg/dl) >40 <40 | 53.6 (13.4) 91% 9% | 52.5 (12) 89% 11% | 52.3 (12.8) 81% 19% | 50.4 (13.6) 87% 13% | NS |
| LDL (mg/dl) <130 >130 | 100 (26) 88% 12% | 101.8 (30) 82% 18% | 93.2 (24.5) 94% 6% | 102.5 (27.9) 82% 18% | NS |
| *One-Way Analysis of variance (ANOVA), P < 0.05. **x2 test, P < 0.05. | |||||
Conclusions: Obese children with BMI ≥2.5SDS do not present dyslipidemia and have similar lipidemic profile to those with BMI <2.5SDS or normal weight children.
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