ESPE Abstracts (2021) 94 P2-223

Fat, metabolism and obesity

Absence of dyslipidemia in obese children with BMI ≥2.5SDS and similar lipidemic profile to those with BMI <2.5SDS or normal weight

Sofia Leka-Emiri1, Maria Dikou1, Catherine Evangelopoulou1, Maria Kafetzi2, Vasilios Petrou1, Elpis Vlachopapadopoulou1 & Stefanos Michalacos1

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1Division of Endocrinology-Growth and Development, “P&A Kyriakou” Children’s Hospital, Athens, Greece; 2Division of Biochemistry-Hormonology, “P&A Kyriakou” Children’s Hospital, Athens, Greece


Objective: Compare triglycerides, total cholesterol, HDL and LDL levels between obese and normal weight children.

Methods: 547 children (286 females) with BMI (≥0SD) were divided in four groups (Group 1: 0SD<BMI<2SD, Group 2: 2SD≤BMI<2.25SD, Group 3: 2.25SD≤BMI<2.5SD, Group 4: BMI≥2.5SD) and analyzed retrospectively from the medical records. Age, sex, BMI z-score, triglycerides, total cholesterol, HDL and LDL (mg/dl) levels were recorded. One-Way Analysis of variance (ANOVA) and x2 test (P < 0.05) were calculated among groups using the SPSS statistics programme.

Results: Mean age was 9.5yrs (SD, 3.07), BMI: 2.28(SD, 0.59), Total cholesterol: 166.9 (SD, 32.7), triglycerides: 81.5 (SD, 46.2), HDL: 52.3 (SD, 13.0), LDL: 99.5 (SD, 27.3). Clinical and laboratory characteristics are summarized in table 1. There was neither statistically significant difference in the sex distribution nor statistically significant difference in the lipidemic profile among the four groups. Obese children were more often prepubertal as opposed to normal weight children (P < 0.05).

Table 1 Clinical and laboratory characteristics, Mean (SD).
Group 1
(n = 157)
Group 2
(n = 130)
Group 3
(n = 124)
Group 4
(n = 136)
p
Age (yrs)10.9 (2.4)9.7 (2.2)9.5 (2.8)7.6 (3.6)*
Sex (males/females)67/9063/6760/6471/65NS
Tanner 1/>243%/57%65%/35%64%/36%76%/24%**
BMI z-score1.7 (0.27)2.1 (0.06)2.4 (0.08)2.9 (0.65)*
Total cholesterol (mg/dl)
<200
>=200
164.5 (34.1)
86%
14%
171 (35)
79%
21%
160.7 (28.9)
89%
11%
169.5 (31.7)
86%
14%
NS
Triglycerides (mg/dl)
<100
>=100
75.9 (39.4)
82%
18%
85.8 (44.3)
73%27%
81.7 (59.1)
76%
24%
83.6 (41.3)
76%
24%
NS
HDL(mg/dl)
>40
<40
53.6 (13.4)
91%
9%
52.5 (12)
89%
11%
52.3 (12.8)
81%
19%
50.4 (13.6)
87%
13%
NS
LDL (mg/dl)
<130
>130
100 (26)
88%
12%
101.8 (30)
82%
18%
93.2 (24.5)
94%
6%
102.5 (27.9)
82%
18%
NS
*One-Way Analysis of variance (ANOVA), P < 0.05.
**x2 test, P < 0.05.

Conclusions: Obese children with BMI ≥2.5SDS do not present dyslipidemia and have similar lipidemic profile to those with BMI <2.5SDS or normal weight children.

Volume 94

59th Annual ESPE (ESPE 2021 Online)

Online,
22 Sep 2021 - 26 Sep 2021

European Society for Paediatric Endocrinology 

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