ESPE Abstracts (2022) 95 P1-530

ESPE2022 Poster Category 1 Growth and Syndromes (85 abstracts)

Proportions of abnormal growth parameters in extremely low birth weight infants (ELBW) during the first 3 years of life: weight Z score(WAZ), length Z score (LAZ), weight for length Z score (WLZ), and head circumference Z score (HCZ)

Fawzia Alyafei , Ashraf Soliman , Fatima Alkhori , Hamdy Ali , Nada Alaaraj , Noor Hamed , shayma Ahmed , Noora Alhemaidi & Saleha Abbasi


Hamad General Hospital, Doha, Qatar


Introduction: This study evaluated the postnatal growth of infants born with extremely low birth weight (ELBW) < 1 kg for 3 years.

Method: Anthropometric measures (z scores) from birth, 2,4.6,12,18,24, and 36 months were measured in 87 randomly selected infants who were born with a birth weight below 1 kg (9-2016: 9-2018). Their growth data were compared to standard growth for normal age and sex using WHO growth standards without correction for gestational age. All ELBW received preterm formula for an average of 4-6 months.

Results: Their gestational age (GA) at delivery ranged between 23 and 27.5 weeks. They had weight z score (mean +/- SE) (WAZ) = -7.7 +/-0.14, length Z score (LAZ) = -8.8 +/-0.25 and Weight for length Z score (WLZ) =-5.6 +/-0.39 and head circumference z score (HCZ) = -8.8 +/-0.3. At birth, 97% of infants had WAZ < -2, 96% had LAZ < -2 and 98.5 % had WLZ <-2. By the age of 18 months, 18.7 % had LAZ < -2, 16.7% had WAZ <-2 and 6% had WLZ <-2. By the age of 3 years 10 % had LAZ < -2, 19 % had WAZ <-2 and 7.4 % had WLZ <-2. At 3 years of age, 14.8 % of infants had WLZ > 1 < 2 and 7.4% WLZ >2. At birth 98.5 % of infants had HCZ <-2 and at 3 years of age only 8.5% had HCZ <-2 denoting very good brain growth.

Table: Proportions of abnormal postnatal growth (%) in infants born With ELBW at different ages.
  % at birth % at 18 mon % at 24 mon % at 36 mon
WAZ <-2 97% 16.67% 14.00% 22.00%
WAZ <-1 100% 35.00% 34.00% 40.00%
WAZ >2 0 5.00% 14.00% 2.00%
WAZ >1 0 11.67% 38.00% 12.00%
LAZ < -2 96% 18.75% 14.00% 10.00%
LAZ <-1 98.5% 53.13% 38.00% 20.00%
WLZ <-2 98.5% 6.00% 17.14% 19.00%
WLZ < -1 100% 24.00% 28.57% 29.00%
WLZ >2 0 5.00% 5.71% 7.41%
WLZ >1 0 16.67% 14.29% 14.81%
HCZ <-2 98.5% 18.00% 8.5% ND
HCZ <-1 100% 56.00% 31.43% ND

Conclusion: Infants born ELBW who were fed preterm formula had progressive improvement of growth parameters including WAZ, LAZ, WLZ, and HCZ. By the age of 3 years, 78% had normal WAZ, 90% had normal LAZ, 87% had normal WLZ, and 91.5% had normal HCZ. Overweight was detected in 7.4% of them at 3 years.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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