ESPE Abstracts

ESPE Abstracts

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60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

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The 60th ESPE Annual Meeting will now be taking place in Rome, Italy.

Poster Category 2

Fat, Metabolism and Obesity

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Diabetes and Insulin
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Fetal, Neonatal Endocrinology and Metabolism

hrp0095p2-92 | Fat, Metabolism and Obesity | ESPE2022

Different profiles of lipoprotein particles associate various degree of cardiac involvement in adolescents with morbid obesity

Arciniegas Larry , M. Siurana José , Sabate-Rotes Anna , Amigó Núria , Martínez-Micaelo Neus , Riaza Lucia , Mogas Eduard , Rosés-Noguer Ferran , S. Ventura Paula , Yeste Diego

Introduction: Dyslipidemia secondary to obesity is a risk factor related to cardiovascular disease events, however a pathological conventional lipid profile (CLP) is infrequently found in obese children. The objective of our study is to evaluate the advanced lipoprotein profile (ALP) and its relationship with cardiac changes, metabolic syndrome and inflammatory markers in a population of morbidly obese adolescents with normal CLP and without type 2 diabetes me...
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hrp0095p2-93 | Fat, Metabolism and Obesity | ESPE2022

The Relationship Between Serum AMH Levels and Puberty in Obese Girls

Sarikaya Emre , Cicek Dilek , Gok Ebru , Kara Leyla , Gul Siraz Ulku , Hatipoglu Nihal

Objectives: Anti-Müllerian hormone (AMH) is produced by Sertoli cells in the testicles and granulosa cells in the ovaries. Increased abdominal adipose tissue initiates metabolic and endocrine disorders and predisposes to polycystic ovary syndrome. AMH is used as a marker in PCOS. A decrease in AMH levels has been reported in adults with obesity and increased central adiposity. The purpose of this study was to assess the serum AMH level and related factors...
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hrp0095p2-94 | Fat, Metabolism and Obesity | ESPE2022

Liraglutide associated with a multidisciplinary program for the treatment of adolescents obesity in a low income setting: a real life experience

Griffero Mariana , Mericq Verónica

Background: The prevalence of childhood obesity is increasing worldwide and Glucagon-like peptide 1 analogs have emerged as a new tool for its management. To date, Liraglutide has been approved for the treatment of obesity in adolescents over 12 years of age by the FDA & EMEA and in Chile (July 2021).Objectives: evaluate the % decrease in BMI SDS and total body fat percentage in adolescents with obesity who received ...
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hrp0095p2-95 | Fat, Metabolism and Obesity | ESPE2022

Compliance and drop-out in children and adolescents with essential obesity

Ferraloro Chiara , Casto Celeste , Corica Domenico , Pepe Giorgia , Valenzise Mariella , Francesca Messina Maria , Arena Giada , Aversa Tommaso , Wasniewska Malgorzata

Introduction: Pediatric obesity is associated with an increased risk of serious long-term complications. Therapeutic failure is influenced by several factors, such as the high dropout rate. A retrospective study was conducted on a cohort of children and adolescents with essential obesity, in order to evalute (1)the average duration of a correct follow-up and the percentage of weight loss at the end of it, (2)the rate of drop-out, researching related factors.</...
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hrp0095p2-96 | Fat, Metabolism and Obesity | ESPE2022

SGPT and FT4 correlations among Greek school age children with obesity or severe obesity

Leka-Emiri Sofia , Kosteria Ioanna , Vlachopapadopoulou Elpis , Dikaiakoy Eirini , Evangelopoulou Catherine , Kafetzi Maria , Petrou Vasilios , Michalacos Stefanos

Background/Aims: Pediatric obesity remains an ongoing serious international health concern. Whether liver dysfunction is related to thyroid dysfunction in this population is controversial. Compare SGPT, TSH, FT4 and insulin resistance indexes between children with obesity or severe obesity.Methods: 279 children (143 females) with ΒΜΙ (≥95percentile) (CDC BMI curves) were divided in two groups (Group 1, ob...
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hrp0095p2-97 | Fat, Metabolism and Obesity | ESPE2022

Linear growth and prevalence of the different components of the metabolic syndrome (MetS) in young obese nondiabetic children (below 5 years) in comparison to older obese children (6-12 years)

Hamed Noor , Soliman Ashraf

Introduction: In Qatar, the prevalence of metabolic syndrome (MetS) in children and adults is increasing in parallel with the markedly increasing trends in obesity rates. We studied the prevalence of different components of MetS, measure plasma atherogenic indexes (AIP), and linear growth in young obese nondiabetic children (< 5 years) in comparison to older obese children (6-12 years).Methods: We analyzed the anthrop...
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hrp0095p2-98 | Fat, Metabolism and Obesity | ESPE2022

Effects of long-term metreleptin replacement therapy on weight and comorbidities in a patient with bioinactive leptin

Zorn Stefanie , von Schnurbein Julia , Kohlsdorf Katja , Brandt Stephanie , Wabitsch Martin

Introduction: Congenital leptin deficiency can be treated with the human leptin analogon metreleptin as first reported in 1999. To date, the long-term effects (> 1 year) of metreleptin treatment on anthropometry and comorbidities have only been described in 8 patients with leptin deficiency. Here, we present the long-term effects of metreleptin substitution on weight and comorbidities in a patient with bioinactive leptin.Metho...
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hrp0095p2-99 | Fat, Metabolism and Obesity | ESPE2022

Gender differences in Italian pediatric obese subjects

Inzaghi Elena , Tarissi Isabella , Deodati Annalisa , Fintini Danilo , Villani Alberto , Cianfarani Stefano

Background: Significant aspects of metabolic homeostasis are regulated differently in males and females and sex differences can influence diagnostic approach and therapeutic responses. The underlying mechanisms accounting for gender difference remain to be established and may involve genetic and hormonal factors.Aim: This study aimed at evaluating gender differences in anthropometric and metabolic parameters in a large c...
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hrp0095p2-100 | Fat, Metabolism and Obesity | ESPE2022

Comparison between Triglyceride-Glucose Index (TyG) and Atherogenic index of plasma (AIP) in relation to the different components of the metabolic syndrome (MetS) in morbidly obese children

Hamed Noor , Soliman Ashraf , Alaaraj Nada , Ahmed Shayma

Background: Metabolic syndrome (MetS) is related to increased cardiovascular complications of obesity. The triglyceride-glucose (TyG) index is frequently used as an indicator of insulin resistance in adults. However, there is scant information on the TyG index in the morbidly obese Pediatric population, nor is its correlation with the components of the metabolic syndrome (MetS).Methods: We compared the use of TyG vs athe...
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hrp0095p2-101 | Fat, Metabolism and Obesity | ESPE2022

Epicardial fat, interventricular septal and leftventricular posterior wall thicknesses are associated with cardiometabolic risk markers and physical activity in apparently healthy school-age children

Vasileva Fidanka , Carreras-Badosa Gemma , Serrano-Ferrer Juan , Gómez-Vilarrubla Ariadna , Mas-Parés Berta , Osiniri Inés , Bassols Judit , Font-Llado Raquel , López-Bermejo Abel , Prats-Puig Anna

Introduction: Inactivity in children is associated with cardiometabolic risk, while physical activity improves cardiometabolic health. We aimed to determine the association between epicardial fat (Efat), interventricular septal and left ventricular posterior wall thicknesses (IVSthickness and LVPWthickness) with physical activity/inactivity, non-sedentary/sedentary behavior, body composition, and cardio-metabolic parameters in children classified as being: ina...
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hrp0095p2-102 | Fat, Metabolism and Obesity | ESPE2022

Long term effect of metformin therapy in children and young people with obesity - A single center experience

Suntharesan Jananie , Pickles Rosanna , John Reed , Apperley Louise , Senniappan Senthil

Introduction: The prevalence of childhood obesity is increasing worldwide, and the management remains a challenge. The mainstay of management is lifestyle modification but if this is not successful, pharmacological agents are considered although the options in children and young people are quite limited. Metformin has been used as an adjunct therapy alongside lifestyle modification in children and young people with obesity. Some studies have shown it to be eff...
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hrp0095p2-103 | Fat, Metabolism and Obesity | ESPE2022

Reduction of The Nutritional Diagnosis of Eutrophy Among Brazilian Adolescents, Evaluation From 2010 to 2021

Machado Pinto Renata , Marinho de Jesus Luciana , Barreira Duarte de Sousa Mariana , Karoliny da Cunha Santos Viviane , Nascimento Fernandes Franco Nathália , Rodrigues Cardoso Jaína , Oliveira Alves Bruna

Introduction: Identifying the nutritional diagnosis of adolescents is crucial for developing public health strategies that promote the adequate development of this population.Objective: To analyze the temporal trends of the BMI of Brazilian adolescents (10 to 19 years old) between 2010 and 2021.Methods: Descriptive ecological study. Data obtained from e-SUS Primary Care. The preval...
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hrp0095p2-104 | Fat, Metabolism and Obesity | ESPE2022

Leptinemia and cardiometabolic risk factors in genetic obesity syndromic in children : Prader Willi and Bardet Biedl

Touzani Asmae , Drai Jocelyne , Balafrej Amina , Gaouzi Ahmed , Chabraoui Layachi

Obesity is a state of imbalance between food intake and energy expenditure leading to a positive energy balance. This condition may be due to the existence of a genetic syndrome: the Prader-Willi syndrome (PWS) is the genetic cause the most common obesity and Laurence-Moon Bardet-Biedl syndrome (BBS), autosomal recessive.Objectives: Our objective is to compare the cardio-metabolic risk factors in children with obesity gene to those of ch...
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hrp0095p2-105 | Fat, Metabolism and Obesity | ESPE2022

A Comprehensive Multidisciplinary Management Plan Is Effective in Reducing the Prevalence of Overweight and Obesity in Adolescence

Binou Maria , Tragomalou Athanasia , Ramouzi Eleni , Koutaki Diamanto , Vourdoumpa Katerina , Manou Maria , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia

Background: Obesity in adolescence represents a major health problem of our century owing to its epidemic proportions and the associated morbidity and mortality in adult life. In Greece, 41% of adolescents are overweight or obese.Aim: The aim of our study was to investigate the effectiveness of a comprehensive, multidisciplinary, personalized management plan at reducing the prevalence of overweight and obesity in adolesc...
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hrp0095p2-106 | Fat, Metabolism and Obesity | ESPE2022

Identification of a novel point mutation in APOB gene in a patient with hypobetalipoproteinemia

Yun Park So , Sik Kim Heung , Lee Donghyun , Kang Seokjin

Familial hypobetalipoproteinemia (FHBL) is an autosomal codominantly inherited disorder of lipid metabolism characterized by <5th percentile plasma levels of LDL cholesterol or total apolipoprotein B (apoB). LDL cholesterol level is usually between 20-50 mg/dL. FHBL results from mutations in APOB, PCSK9 gene. Patients with homozygous APOB-related familial hypobetalipoproteinemia (APOB-FHBL) may have symptoms of fat malabsorption, steatorrhea, diarrhea, failure to thrive, de...
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hrp0095p2-107 | Fat, Metabolism and Obesity | ESPE2022

An Obese Patient with A Pathogenic PTEN Mutation. A Case Report

Vourdoumpa Aikaterini , Koutaki Diamanto , Paltoglou George , Fryssira Elena , Charmandari Evangelia , Bacopoulou Ioanna

Introduction: Germline mutations in Phosphatase and tensin homolog (PTEN) gene (chromosome 10q23) lead to PTEN Hamartoma Tumor Syndrome (PHTS), which includes Cowden syndrome. PTEN encodes a tumor suppressor protein that is a negative regulator of PI3K – Akt signaling pathway, taking part in multiple biological processes, including cellular cycle and regulation of metabolism.Materials and Methods:...
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hrp0095p2-108 | Fat, Metabolism and Obesity | ESPE2022

A Noval De Novo PHIP Variant Contributing to Chung-Jansen Syndrome: a case report and review

Huang Feiyan , Liang Liyang , Hou Lele , Zhang Lina , Meng Zhe

Objectives: To present Chung-Jansen Syndrome or CHUJANS by a de novo variant in the pleckstrin homology domain-interacting protein (PHIP) gene and compare the clinical phenotype with previous case reports; ②To provide a novel genetic detection methods with whole-exome sequencing(WES) and whole genome sequencing(WGS) and Sanger sequencing for rare genetic diseases.Patients and methods: Following collecting clinical...
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hrp0095p2-109 | Fat, Metabolism and Obesity | ESPE2022

Updated reference ranges for aminotransferase levels of Korean children and young adolescents based on the risk factors for metabolic syndrome

Seo Young-Jun , Suk Shim Young , Sang Lee Hae , Soon Hwang Jin

We investigated the reference values of liver enzymes based on cardiometabolic risks among children and adolescents using the Korea National Health and Nutrition Examination Survey (KNHANES). A total of 8,091 subjects aged 10-18 years were included data from 2007-2017. Overall, Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the AST/ALT ratio varied with sex and age. AST levels tended to decrease with age, but ALT levels had a U-shaped curve, which result...
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hrp0095p2-110 | Fat, Metabolism and Obesity | ESPE2022

Uric Acid as A Marker of Cardiovascular Risk and Insulin-Resistance in Course of Pediatric Obesity

Guercio Nuzio Salvatore , D'Isanto Livio

Introduction: Many evidences confirmed that hyperuricemia is connected with obesity, insulin resistance, type 2 diabetes and cardiovascular risk, not only among adults. Uric acid (UA) interacts with other factors in the modulation of obesity and its complications, since childhood. The study aims to identify any correlations between AU plasma concentrations and the clinical/laboratory data of a group of obese Italian children living in the province of Salerno, ...
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hrp0095p2-111 | Fat, Metabolism and Obesity | ESPE2022

Gamma-Glutamyl Transferase (GGT) and The GGT / High-Density Lipoprotein (HDL) Ratio: Useful Tools for Identification of OBESE Children with Insulin Resistance

Nuzio Salvatore Guercio , Livio D'Isanto

Introduction: The role of gamma-glutamyl transferase (GGT) enzyme as a marker of insulin resistance (IR) in pediatric obesity is well known. Recent evidence, mainly in the adult population, has identified GGT/High-Density Lipoprotein (HDL) ratio as a risk index for hepatic steatosis. The study has the purpose of examining the relationship between GGT, GGT/HDL ratio and the clinical/laboratory data of a group of obese Italian children living in the province of ...
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hrp0095p2-112 | Fat, Metabolism and Obesity | ESPE2022

Prediabetes in Obesity Adolescents: Frequency, Structure, Relationship with Body Mass Index

Minkova Nadezda , Latyshev Oleg , Kiseleva Elena , Okminyan Goar , Romaykina Daria , Samsonova Lubov

Background: The increased prevalence of youth obesity has led to raised youth-onset type 2 diabetes mellitus (T2DM), as well as the intermediate condition of prediabetes. Diagnosis of prediabetes can help preventing of the development of T2DM.Aims: to study the frequency, clinical laboratory diagnostics and relationship of prediabetes with SDS BMI in obese adolescents.Materials: Th...
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hrp0095p2-113 | Fat, Metabolism and Obesity | ESPE2022

Binge eating disorder in children with different forms of obesity

Waaks-Stępień Bogdan , Mikhno Hanna , Malastseva Lizaveta

Background: Binge-consuming disorder(BE) is mental ilness where people eats large amounts of food over a short period of time with associated negative psychological problems, but wihout the compensatory behaviors. Nowadays this illness is more common in obese children.Objective: To evaluate the frequency of compulsive overeating in children with obesity.Methods: We examined 148 chi...
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hrp0095p2-114 | Fat, Metabolism and Obesity | ESPE2022

Leptin receptor deficiency: a case report

Zufarova Yulduz , Kolodkina Anna , Tiulpakov Anatoly

Background: Leptin receptor deficiency leads to severe early-onset obesity and pituitary dysfunction. Here we present the first case of monogenic obesity due to a novel mutation in LEPR gene in Russia.Case report: 16-year-old female patient was admitted to our hospital with morbid obesity and primary amenorrhea. She was born at term with a birth weight of 3360 g to non-consanguineous parents. She had a mild deve...
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hrp0095p2-115 | Fat, Metabolism and Obesity | ESPE2022

Is it Hyponatremia or Pseudohyponatremia? Management of Low Serum Sodium in Patient with Acute Pancreatitis Secondary to Hypertriglyceridemia

Alsaffar Hussain , Al-Mamari Moza , Al-Mamari Salim , AlShidhani Azza

Background: Hyponatremia is an electrolyte disorder, that may lead to severe complications such as rhabdomyolysis, seizures, coma, and death. Clinicians do take hyponatremia seriously. However sometimes clinicians should be careful in interpreting the low laboratory sodium level as it does not necessarily reflect the actual natremic status especially when the patient is euvolemic and having normal serum osmolality, for which pseudohyponatremia should be consid...
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hrp0095p2-116 | Fat, Metabolism and Obesity | ESPE2022

Abstract Withdrawn...
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hrp0095p2-117 | Fat, Metabolism and Obesity | ESPE2022

Cardiometabolic risk factor clustering in obese adolescents

La Grasta Sabolić Lavinia , Požgaj Šepec Marija , Valent Morić Bernardica , Stipančić Gordana

Introduction: The increasing prevalence of obesity has become a major global health issue. Clustering of cardiometabolic risk factors in obese adolescents is associated with reduced life expectancy and impaired quality of life. Due to serious impact of obesity on cardiometabolic health, effective treatment strategies are intensively sought after.Objectives: The aim of this retrospective cross-sectional study was to exami...
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hrp0095p2-118 | Fat, Metabolism and Obesity | ESPE2022

Relationship Between Neck Circumference and Cardiometabolic Risk in Children and Adolescents with Obesity

Guercio Nuzio Salvatore , D'Isanto Livio

Introduction: Pediatric obesity (PO) if not adequately identified and addressed, leads to significant chronic diseases in adulthood. The anthropometric methods for the evaluation of PO have limitations well described in the literature. Neck circumference (NC) is recently proposed as parameter for better identification and evaluation of PO. We verified the relationship between NC, body mass index (BMI), waist circumference (WC) and some laboratory parameters of...
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hrp0095p2-119 | Fat, Metabolism and Obesity | ESPE2022

Abstract Withdrawn...
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hrp0095p2-120 | Fat, Metabolism and Obesity | ESPE2022

Evaluation of Thyroid Function among children and adolescents with obesity

Nourbakhsh Mona , Ramezani Nastaran , Nourbakhsh Mitra , Razzaghy Azar Maryam

Introduction: Obesity is a rapidly growing health problem, with increasing worldwide prevalence. Obesity is accompanied by numerous metabolic and endocrine dysregulation. Thyroid dysfunction is one of the many metabolic aberrations that are associated with obesity. Thyroid dysfunction can be related to obesity, insulin resistance, and dyslipidemia. We aimed to study the thyroid function in children and adolescents with obesity and the metabolic parameters....
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hrp0095p2-121 | Fat, Metabolism and Obesity | ESPE2022

Age-related cardiometabolic risk in children and adolescents

Bizerea-Moga Teofana-Otilia , Loredana Pantea Cristina , Olah Orsolya , Marginean Otilia

Obesity, the silent pandemic of the 21st century, is being observed at increasingly younger ages. Included in the metabolic syndrome (MetS), it creates a favorable environment for the development of other components, such as impaired glucose tolerance (IGT), insulin resistance (IR), dyslipidemia (DysL) and arterial hypertension (HT). The aim of this study was to asses the influence of birth weight for gestational age (BW-GA) and age on the occurence of MetS and its components....
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hrp0095p2-122 | Fat, Metabolism and Obesity | ESPE2022

Pediatric Endocrine evaluation of Marfan syndrome: A case report

Koutaki Diamanto , Vourdoumpa Aikaterini , Bacopoulou Ioanna , Fryssira Helen , Charmandari Evangelia , Paltoglou George

Background: Endocrine disorders associated with tall stature in childhood are frequently evaluated by Pediatric Endocrinologists. The most common non-endocrine genetic cause of tall stature, Marfan syndrome, is a rare autosomal dominant genetic condition of the connective tissue, which presents with specific dysmorphic features, including thin physique, long extremities and normal growth rate. Little is known regarding the association of Marfan syndrome with o...
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hrp0095p2-123 | Fat, Metabolism and Obesity | ESPE2022

Diagnosis and management of childhood obesity during COVID-19 pandemic: an audit on clinical practice in a tertiary center

Pop Raluca-Monica

Background: Childhood obesity represents an important public health problem and its diagnosis and management should be based on current guidelines. Prevalence of childhood obesity in Romania is one of the lowest in Europe but with a positive trend.Aim: The aim of the current study was to analyze the implementation of the recommendations of the 2017 Endocrine Society Clinical Practice Guideline on Assessment, Treatment an...
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hrp0095p2-124 | Fat, Metabolism and Obesity | ESPE2022

Abstract Withdrawn...
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hrp0095p2-125 | Fat, Metabolism and Obesity | ESPE2022

Effects of confinement due to COVID-19 in the child population of Álava on vitamin D status, weight and body composition

and body composition weight , Aguirre-Lopez Leixure , Puy Portillo-Baquedano Mari , Fernandez-Quintela Alfredo , Leniz-Rodríguez Asier , Diez-Lopez Ignacio

The coronavirus disease (COVID-19) pandemic brought with it a state of alarm as of March 14, 2020, which implied a restriction on the mobility of the general population and home confinement. One of the main concerns raised by isolation was the substantial reduction in energy expenditure due to children spending more time sitting or participating in activities that involve very low rates of energy expenditure, such as watching television, managing the different networks social ...
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hrp0095p2-126 | Fat, Metabolism and Obesity | ESPE2022

Vitamin D, OPG in Obese Children

Mikhno Hanna , Solntsava Anzhalika

Objective: Determination of changes in metabolic status and vitamin D concentrations in obese children.Methods: We examined 210 children in the University Hospital (Minsk) from 2021 to 2022 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, OPG, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO) ...
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hrp0095p2-127 | Fat, Metabolism and Obesity | ESPE2022

The effects of Long-term (five years) Prednisone Therapy in Frequently Relapsing Nephrotic Syndrome of Childhood: Impact on glycemia and the different components of the metabolic syndrome (MetS)

Hamed Noor , Soliman Ashraf , Alaaraj Nada , Ahmed Shayma , Alyafei Fawzia , Itani Maya , Al-Naimi Fatima , Al-Yousef Doaa , Shaat Mona , El Baba Mostafa

Although widely prescribed for their anti-inflammatory and immunosuppressive properties, glucocorticoids have various common metabolic side effects including hypertension, dysglycemia, and diabetes. Proposed risk factors for steroid-induced dysglycemia and metabolic syndrome include cumulative dose, longer duration of steroid course, and high body mass index.Aim: This study was carried out to investigate the prevalence of different metab...
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