ESPE Abstracts (2022) 95 P1-485


1Department of Pediatrics, Medical Faculty of Comenius University and National Institute for Children´s Diseases, Bratislava, Slovakia; 2Department of Metabolic Disease Research, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia

Background and Aims: Thyroid hormones profoundly affect energy metabolism but their interrelation with food preference, which might contribute to childhood obesity development, are much less understood. Here we investigated if age-related changes of thyroid hormone levels are paralleled by specific modulation of food preference and potentially linked to the level of obesity in children and adolescents.

Patients and Methods: Interrelations between food preference and peripheral thyroid activity were examined in a population of 99 non-obese and 101 obese children and adolescents (12.8±3.6 yrs. of age, 112/89 F/M) randomly selected from the patients of Obesity and Metabolic Disease Out-patient Research unit at NÚDCH in Bratislava in a period between 12/2017 and 3/2020.

Results: Obese children and adolescents had lower preference for the food rich in high sucrose, and high-complex carbohydrates, while the preference for protein and fat containing food and that for dietary fibers was identical in obese and non-obese. In obese adolescents positive correlations of FT4 with the preference for high protein, high fat rich diet was found irrespective of the fatty acid unsaturation level. Moreover, FT4 correlated negatively the preference for dietary fibers which was also exclusively found in obese adolescents. Obese individuals with higher FT4 levels (stratified by median value) had higher systemic levels of AST and ALT then the low FT4 group. Multiple regression analysis with age, sex, BMI-SDS and FT4 as co-variates revealed, that FT4 and gender are the major predictors of variability in the preference for diet high in protein, fat and monounsaturated fatty acids. FT4 was the sole predictor of the preference for diet containing saturated and polyunsaturated fatty acids as well as for diet low in fibers.

Conclusions: Serum levels of thyroid hormone FT4 were significantly associated with food preferences in obese children and adolescents. This may indicate that FT4 could contribute to development of childhood obesity and its complications by modulating food preference. Grant support: VEGA 1/0308/19 and KEGA 053UK-4/2020.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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