ESPE2022 Poster Category 2 GH and IGFs (14 abstracts)
GH responsiveness and IGF1 P2 promotor methylation
Anja Apel 1 , Daniel I. Iliev 1 , Christina Urban 1 , Karin Weber 1 , Roland Schweizer 1 , Gunnar Blumenstock 2 , Sarah Pasche 3 , Vanessa Nieratschker 3 & Gerhard Binder 1
1University-Children's Hospital, Pediatric Endcorinology, Tübingen, Germany; 2Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany; 3Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University Hospital Tübingen, Tübingen, Germany
Background: The methylation of IGF1 promoter P2 was reported to negatively correlate with serum IGF-1 concentration and rhGH treatment response in children with idiopathic short stature. These findings have not yet been confirmed.
Objective: This study aimed to determine IGF1 promoter P2 methylation in short children treated with rhGH and correlate clinical parameters with the methylation status. In addition, long-term stability of methylation during rhGH treatment was studied.
Design: This was a single tertiary center study analyzing clinical GH response and IGF-1 serum concentration changes in patients with GHD (n=40), SGA short stature (n=36), and Turner syndrome (n=16) treated with rhGH. Data were correlated to the methylation of two cytosine residues (-137, +97) of the P2 promoter of IGF1 in blood cells measured by pyrosequencing in 443 patient samples.
Results: Basal and stimulated IGF-1 concentrations, first year increment in height velocity and studentized residuals of a prediction model did not correlate to the methylation of -137 und +97 in IGF1 P2 promoter. The methylation of these two sites was relatively stable during treatment.
Conclusions: This study did not confirm IGF1 P2 promotor being a major epigenetic locus for GH responsiveness in patients treated with a normal dose of rhGH. Additional studies are warranted.
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