ESPE2022 Poster Category 2 Diabetes and Insulin (43 abstracts)
Low vitamin D levels are associated with markers of metabolic syndrome in children with newly onset type 1 diabetes mellitus
Elsa Puerto-Carranza 1 , Liria Muriscot-Niell 1 , Gemma Carreras-Badosa 2 , Francis De Zegher 3 , Ibañez Lourdes 4 , Bassols Judit 2 & López-Bermejo Abel 2,1
1Pediatrics, Dr. Josep Trueta University Hospital, Girona, Spain; 2Pediatric Endocrinology Group, [Girona Biomedical Research Institute] IDIBGI, Salt, Spain; 3Department of Development & Regeneration, University of Leuven, Leuven, Belgium; 4Pediatric Research Institute, Sant Joan de Déu Children’s Hospital, Barcelona, Spain
Background: Low vitamin D levels are prevalent in pediatric patients with type 1 diabetes mellitus (T1DM) and are associated with increased risk for insulin resistance, type 2 diabetes mellitus and cardiovascular disease. Little is known about associations between vitamin D levels and markers of metabolic syndrome in incident T1DM in children. The aim of our study was to analyze associations between D vitamin levels and metabolic markers in newly onset T1DM pediatric patients.
Methods: Subjects were 34 children with T1DM (57% girls; median age 9.6 +/-3.4 years) who were studied at time of diagnosis. Anthropometrics were assessed and laboratory parameters were measured in fasting blood samples (25-OH vitamin D, triglycerides, LDL- and HDL-cholesterol, glucose, insulin and HbA1c). The relationship between variables was analyzed by Pearson correlation followed by multiple regression analyses.
Results: Lower vitamin D levels were associated in these children with and adverse lipid profile, consisting in higher triglyceride (β= –0.392; P=0.02; adjusted R2=0.126) and lower HDL levels (β=0.437; P=0.01; adjusted R2=0.160), independently of age, sex and BMI. These associations were also relevant for the HDL/triglycerides ratio (β=0.494; P=0.003; adjusted R2 =0.219).
Conclusions: In newly onset pediatric type 1 diabetic patients, lower vitamin D concentrations are independently associated with markers of metabolic syndrome such as serum triglycerides and HDL-cholesterol. Our results indicate that incident T1DM pediatric patients with lower vitamin D concentration may present an increased metabolic risk compared to those with adequate vitamin D levels.
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