ESPE Abstracts

Introduction: The hypothalamo-pituitary system is activated as puberty begins and GnRH release occurs as well as the synthesis of many hormones. These hormones cause changes on muscle development, body fat distribution. In this study, changes in miyostatin, irisin, kisspeptin, omentin and leptin levels and the relationship of these changes with physical properties and fat tissue were investigated.

Material and Method: A total of 150 healthy children; between the ages of 8 and 16; with equal distribution of boys and girls; were included in the study. Serum irisin, omentin, leptin, kisspeptin and myostatin levels were analyzed by ELISA method. The study was supported by the Scientific Research Projects Commission of Atatürk University with the code TTU-2020-8610.

Results: Serum leptin level was 322.27 ± 773.64 µL in girls and 228.89 ± 713.84 µL in boys. The serum omentin level was 37.2 ± 16.47 ng/ml in boys and 31.25 ± 17.84 ng/ml in girls, and there were significant differences between genders, respectively (P<0.001, <0.05). In addition, irisin hormone (P=0.015) and leptin hormone increased statistically significantly as Tanner stage increased in female cases (P<0.05). When the relationship between the anthropometric measurements of the cases and biochemical values of the cases is evaluated; in male cases; between irisin and hip circumference (P<0.001) and BMI (P=0.024), between leptin and hip circumference (P=0.005) and BMI (P=0.001) statistically significant relationship was observed. No correlation was found between other parameters. Also, when investigating the relationship between these hormones; a highly significant positive relationship was found between myostatin and kisspeptin and omentin, and between kisspeptin and irisin (P<0.001). Further, a statistically significant positive relationship was observed between kisspeptin and omentin (P=0.002) and leptin (P=0.043).

Conclusion: In addition to increases in height, weight, BMI, waist, hip circumference, waist/hip circumference ratio, there were significant increases in FSH, LH and E2 levels as puberty progresses. While the waist/hip circumference ratio was higher in boys, indicating central fat deposition in boys. Also, the fact that serum omentin levels were found to be lower and serum leptin levels higher in girls during puberty, emphasizes that serum omentin and leptin levels at puberty are affected by gender.