Previous issue | Volume 97 | ESPE2023

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

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The 61st ESPE Annual Meeting will now be taking place in The Hague, The Netherlands

hrp0097p1-186 | Thyroid | ESPE2023

Comparison of clinical features, therapy, and disease evolution in a population of children and adolescents with Graves' disease and Type 1 Diabetes compared to Graves' disease alone.

Bernardini Luca , Maltoni Giulio , Cristina Vigone Maria , Franceschi Roberto , Cardinale Giuliana , Mameli Chiara , Piscopo Alessia , Roppolo Rosalia , Savastio Silvia , Ortolani Federica , Randazzo Emioli , Giulia Lambertini Anna , Cassio Alessandra

Introduction: About 25% of children and adolescents with Type 1 Diabetes (T1D) have one or more associated autoimmune conditions. Although Graves' disease (GD) rarely occurs, considering the potential severity of manifestations, an early diagnosis and appropriate treatment are essential. The first line treatment is methimazole, whose use is not free from side effects; therefore, it is important to start with the most appropriate dosage.<p class="abste...

hrp0097p1-187 | Thyroid | ESPE2023

Thyroid nodules and differentiated thyroid carcinoma in children and adolescents. Experience of a tertiary pediatric endocrinology center in Greece.

Dikaiakou Eirini , Leka Sofia , Kosteria Ioanna , Athanasouli Fani , Vakaki Marina , Geli Myrsini , Sevaslidou Ioanna , Papadopoulou Katerina , Vlachopapadopoulou Elpis-Athina

Objectives: The aim of this study was to report on the frequency and describe the clinical characteristics of the ones diagnosed as thyroid cancer among all suspicious nodules diagnosed in the pediatric endocrinology department and to compare the findings with recent published literature.Methods: Retrospective study during the last 5 years. Patients aged <18 years, with suspected thyroid nodule malignancy, according t...

hrp0097p1-188 | Thyroid | ESPE2023

DICER1 Syndrome and pediatric thyroid carcinoma

Abbate Marco , Vincenzi Gaia , Maggiore Riccardo , Schiavo Lena Marco , Tarantola Giulia , Teresa Petralia Ilenia , Matilde Tura Adele , Grazia Patricelli Maria , Barera Graziano , Cristina Vigone Maria

DICER1, a gene located on chromosome 14q32.13, encodes a protein ribonuclease (RNase) IIIb that plays a central regulatory role in miRNA processing. DICER1 syndrome has an autosomal dominant inheritance and predisposes affected individuals to a wide variety of tumors, both benign and malignant. We describe the case of a 6-year-old girl, carrier of a DICER1 germline mutation, and affected by a differentiated thyroid carcinoma. At the age of 6 a first thyroid ultrasound revealed...

hrp0097p1-189 | Thyroid | ESPE2023

Anemia-based Screening for Resistance to Thyroid Hormone Alpha in Children

Akın Kağızmanlı Gözde , Kırbıyık Özgür , Abacı Ayhan , Böber Ece , Yiş Uluç , Demir Korcan

Background: Resistance to thyroid hormone alpha (RTH-α) is characterized by varying degrees of symptoms and findings related to hypothyroidism. However, diagnosis is difficult since thyroid-stimulating hormone (TSH) levels are normal. Free triiodothyronine (fT3) and free thyroxine (fT4) levels can also be normal, but normo- or macrocytic anemia is generally present in the reported cases. L-thyroxine can alleviate some symptoms; however, there is limited ...

hrp0097p1-190 | Thyroid | ESPE2023

Pubertal timing and characterization in children with congenital hypothyroidism: How important is preschool age anthropometry?

Güven Ayla , Nurcan Cebeci Ayşe

Introduction: The main purpose of the study was to determine whether anthropometric measurements at preschool (PS)-age, in which physiological adiposity rebound is detected, and LT4 dose have an effect on the age of onset of puberty in children with hypothyroidism.Methods: This is an observational and retrospective study.Results: Puberty had begun in 44 girls and 25 boys out of 115...

hrp0097p1-191 | Thyroid | ESPE2023

Paediatric Graves’ Disease: Presentation, Treatment and Follow up. A Single Centre Experience from United Kingdom.

Vijayan Roopa , Kapoor Ritika , Agrawal Pankaj , Buchanan Charles , Chapman Simon , Arya Ved

Objective: To describe a cohort with paediatric Graves disease followed between 2012 and 2022 at King’s College Hospital, London.Materials and Methods: Retrospective study of 36 patients treated with block and replace regimen of anti-thyroid drugs with a median (range) follow up of 4.25 (1.1-10.8) years. Demographic, clinical, biochemical and treatment data were collected from clinical records. Predictive factors f...

hrp0097p1-192 | Thyroid | ESPE2023

Remission in pediatric hyperthyroidism treated with methimazole

Ricci Jaime , Castro Bethania , Sabino Franco , Fasano Victoria , Tournier Andrea , Balbi Viviana , González Verónica , Morin Analía

Introduction: Hyperthyroidism (HT) is a condition characterized by inappropriately high thyroid hormone (TH) activity at receptor level, due to high synthesis and secretion of TH by thyroid gland. Antithyroid drugs as methimazole (MMI) are used as the first-line therapy in children. However, the optimal treatment duration and the predictive remission factors are still controversial.Objective: To investigate outcome of MM...

hrp0097p1-193 | Thyroid | ESPE2023

Thyroid hormone resistance syndrome due to a new mutation in the TRHA gene

Tuhan Hale , Donbaloğlu Zeynep , Kırbıyık Özgür , Parlak Mesut , Demir Korcan

Introduction: Resistance to thyroid hormones is defined as lack of response of peripheral tissues to triiodothyronine (T3) which is the active form of thyroid hormones. In general (85%) a mutation is detected in the thyroid hormone receptor β (THRB) gene and more rarely, the thyroid hormone receptor α (TRHA) gene.Case: A 4.7-year-old boy, was admitted to the pediatric endocrinology outpatient clinic of Akdeniz...

hrp0097p1-194 | Thyroid | ESPE2023

Predicting variables associated with transient congenital hypothyroidism

Hwa Gwag Si , Hyun Park Kyu , Kang Eungu , Nam Hyo-Kyoung , Rhie Young-Jun , Lee Kee-Hyoung

Background: Increase in incidence of congenital hypothyroidism (CH) is explained by detection of transient CH (TCH), previously commonly underdiagnosed, due to neonatal screening programs. Current guidelines recommend that treatment be started immediately after diagnosis and that hypothalamic-pituitary-thyroid (HPT) axis be reevaluated after 3 years of age. We aimed to identify the factors associated with TCH, such as the perinatal history or L-thyroxine (LT4)...

hrp0097p1-195 | Thyroid | ESPE2023

A rare case of thyroid dyshormonogenesis with high urine iodine excretion

Gunarathna Leslie , Clemente Marisa , Weerasinghe Kamal

Background: Variety of defective thyroid hormone biosynthesis accounts for 15% of congenital hypothyroidism. Children with IYD gene (formerly DEHALI) mutation, which encodes thyroidal enzyme iodotyrosine deiodinase, cannot recycle iodine in thyroid gland. This results in urinary loss of iodine and hypothyroidism. The condition may be missed by neonatal screening programs.Case description: A male baby was born of non-cons...

hrp0097p1-196 | Thyroid | ESPE2023

Clinical Pattern and management attitudes of Paediatric Graves' Disease in Saudi Arabia, A 10-Year Experience

Mulla Jaazeel , Al Shaikh Adnan , Aldubayee Mohammad , AlNoaim Khalid , Hakim S , Babiker Amir

Introduction: Graves’ disease (GD) is a leading cause of hyperthyroidism in all age groups. Clinical presentation, methods and overall goals of therapy can be variable in different age groups. We aimed to study the prevalence of GD, the attitude of treating physicians towards management preferences as well as patient response pattern amongst children and adolescents with GD in Saudi Arabia.Methods: A cross sectiona...

hrp0097p1-197 | Thyroid | ESPE2023

Effects of methimazole therapy on effector T and B regulatory cells in pediatric patients with Graves' disease

Stożek Karolina , Grubczak Kamil , Starosz Aleksandra , Bossowski Filip , Moniuszko Marcin , Bossowski Artur

Introduction: The incidence of autoimmune thyroid diseases (ATD) is constantly rising. Graves’ disease (GD) remains the most common cause of thyrotoxicosis in pediatric population, but the exact pathogenesis of GD is still not fully understood. The immunological basis of ATD assumes an imbalance between effector and regulatory T lymphocytes. B regulatory cells (Breg) are able to suppress the pro-inflammatory properties of effector T cells. Methimazole (M...

hrp0097p1-198 | Thyroid | ESPE2023

Graves’ disease in children with Down syndrome

Nurcan Cebeci Ayse , Schempp Vera , Reinauer Christina , Gohlke Bettina , Marx Michaela , Dörr Helmuth-Günther , Woelfle Joachim

Introduction: Thyroid abnormalities such as subclinical or overt hypothyroidism are common in children with Down syndrome (DS) with ranges from 4% to 19.5%, whereas Graves´ disease (GD) is extremely rare (ranges 0.6%-0.9 %).Aims: To evaluate clinical features, course, and treatment of GD in children with DS.Patients and Methods: Among 161 children with GD, diagnosed between 1...

hrp0097p1-199 | Thyroid | ESPE2023

Investigating the Incidence of Mild Neonatal Hyperthyrotropinaemia, a Multicentre Study

Howard-James N , McGlacken-Byrne SM , Kernan R , Carolan EC , Murphy NP

Background: Mild isolated neonatal hyperthyrotropinaemia (HTT), defined as elevated thyroid stimulating hormone (TSH) with normal free thyroxine (FT4) concentrations, may be identified by newborn screening programmes for congenital hypothyroidism (CHT) or when neonatal thyroid function tests (TFTs) are performed for a clinical indication. Reported HTT incidence rates vary (from 0.001-0.1%)1. Case definition also varies, with some authors using a TSH...

hrp0097p1-383 | Thyroid | ESPE2023

Clinical and molecular characteristics of 147 patients with primary congenital hypothyroidism: A single-center experience

Yavaş Abalı Zehra , Alavanda Ceren , Eltan Mehmet , Arslan Ateş Esra , Helvacioglu Didem , Gurpinar Tosun Busra , Kahveci Ahmet , Kurt İlknur , Keleştemur Elif , Guran Tulay , Bereket Abdullah , Turan Serap

Background: Next-generation sequencing (NGS) technologies have improved our knowledge about the genetic basis of congenital hypothyroidism (CH). The objective of our study was to evaluate the molecular genetic etiology in our primary CH cohort by using the NGS-based panel.Subjects and Methods: The clinical and genetic characteristics of 147 patients (61 female) from 129 unrelated families were evaluated. The patients wer...

hrp0097p1-384 | Thyroid | ESPE2023

A novel X-linked variant [c.1772delG (p.G591fs*20)] in IRS4 in a patient with central hypothyroidism

Koprulu Ozge , Tozkır Hilmi

Central hypothyroidism (CeH) is characterized by thyroid hormone deficiency due to impairment of pituitary TSH or hypothalamic TRH biosynthesis. CeH is often seen as a part of multiple pituitary hormone deficiencies, but it can also be seen as isolated. Diagnosis may be challenging. To date, some variants that can cause isolated CeH have been identified; although in a number of patients the cause has not been clarified. Recently, variants of the insulin receptor substrate 4 (<...

hrp0097p1-385 | Thyroid | ESPE2023

Patients with genetic susceptibility syndromes to thyroid cancer in a tertiary hospital

Andrés Carlos , J. Chueca María , Elcano Leire , Ros Raquel , Berrade Sara , Alonso Angel

The new techniques of molecular genetics are revolutionizing our clinical practice. This causes benefits in the diagnosis and prediction of diseases in patients, but also raises new ethical concerns that must be addressed. One of them is the susceptibility to cancer due to genetic risk. Children can be especially vulnerable in this area, as they do not freely decide the way forward. Regarding thyroid cancer, it is important to know which genetic syndromes are susceptible to ca...

hrp0097p1-386 | Thyroid | ESPE2023

Very early diagnosis of Monocarboxylate Transporter 8 (MCT8) Deficiency by measuring Free Triiodothyronine (fT3) in Infancy

Dubinski Ilja , Weigand Heike , Schmidt Heinrich

Background: Monocarboxylate-transporter 8 (MCT8) deficiency, also known as Allan-Herndon-Dudley syndrome (AHDS), is associated with severe motoric and intellectual developmental delay. The pathophysiology is characterized by central hypothyroidism (due to transporter defect) and peripheral hyperthyroidism with thyrotoxicosis. There is often an increase in the peripheral T3 values and a decrease in the T4 values. In addition, numerous comorbidities can be held ...

hrp0097p1-387 | Thyroid | ESPE2023

Effect of Daily Zinc Supplementation for 12 Weeks on Serum Thyroid Auto-Antibody Levels in Children and Adolescents with Autoimmune Thyroiditis – A Randomized Controlled Trial

G Delhikumar C , Ramge @ Ramachandran Sivakumar , Sahoo Jayaprakash , Bobby Zachariah , Palanivel C

Background: The imbalance between oxidant-antioxidant status plays an essential role in the pathogenesis of many autoimmune diseases, including autoimmune thyroid disease (AITD). Studies have described that children with AITD have reduced superoxide dismutase (SOD), glutathione peroxidase (GPx), and significantly low zinc levels. This study assessed the effect of daily zinc supplementation for 12 weeks on thyroid auto-antibodies - thyroid peroxidase antibody (...

hrp0097p1-388 | Thyroid | ESPE2023

Neutropenia in paediatric Graves disease patients occurs more often under Carbimazole than Methimazole

Schempp Vera , Nurcan Cebeci Ayse , Reinauer Christina , Woelfle Joachim , Dörr Helmuth-Günther , Roosen Marie-Thérèse , Gohlke Jonas , Gohlke Bettina

Introduction: Neutropenia is known as a rare adverse event of anti-thyroid drug treatment (ATD) but has also been reported as pre-treatment neutropenia in Graves’ disease (GD). Studies on paediatric patients are rare. To the best of our knowledge, there are no data comparing the effects of methimazole (MMI) and carbimazole (CBZ) treatment in children on the absolute neutrophil count (ANC).Methods: We analyzed retro...

hrp0097p1-389 | Thyroid | ESPE2023

Long-term follow-up of congenital hypothyroidism and predictors of permanent congenital hypothyroidism

Yang Jaejin , Yu Jeesuk

Purpose: Congenital hypothyroidism (CH) is a state in which thyroid hormones are insufficient at birth. This condition may last for a lifetime or may be transient. Due to the universal newborn screening test, almost all newborns are being screened for thyroid function in Korea. The study was aimed to see the predictors of transient congenital hypothyroidism with long-term follow-up of more than 3 years of CH in a single tertiary center.<...

hrp0097p1-390 | Thyroid | ESPE2023

Abstract withdrawn...

hrp0097p1-391 | Thyroid | ESPE2023

Molecular Genetic Causes In Elevated TSH: Frequency And Genotype-Phenotype Characteristics

Gül Balki Hanife , Parıltay Erhan , Özalp Kızılay Deniz , Gökşen Damla , Darcan Şükran , Özen Samim

Introduction: The most common cause of elevated TSH is iodine deficiency, and other common causes are drug use, systemic diseases, and underlying genetic conditions.Objective: We aimed to investigate molecular genetic etiology, genotype-phenotype relationships and the follow-up data in cases with elevated TSH initiated on L-thyroxine treatmentMethods: We retrospectively evaluated c...

hrp0097p1-392 | Thyroid | ESPE2023

A case series of multinodular goitres associated with tumour predisposition syndromes

Angley Eleanor , Farrell Stephen , Zacharin Margaret

Thyroid nodular disease, either multinodular goitre (MNG) or solitary nodule, carries a higher malignancy risk in paediatric patients compared to adults requiring closer monitoring and investigation. We present a case series of patients with multinodular goitre who were confirmed to have tumour predisposition syndromes. Eight patients (six female) with MNG were identified using electronic medical records, based on presence of MNG and/or previous genetic testing confirming eith...

hrp0097p1-393 | Thyroid | ESPE2023

Primary hydatid cyst of the thyroid gland in a Libyan child

Ghawil Millad , Ben Omar Nesrin , Shatani Amal , Belhaj Salma , Doggah Milad

Background: Cervico-facial hydatid cyst is rare. It has a high incidence rate in regions with a mild climate such as Mediterranean countries, Middle East, South America, New Zealand, Australia and Southeast Asia. Hydatid cyst develops most often in the liver and lungs in human beings. The incidence of hydatid cysts in the thyroid gland is rare and it accounts for 1% of echinococcosis locations. Primary hydatid cyst of thyroid gland is an exceptional localizati...

hrp0097p1-394 | Thyroid | ESPE2023

Assessment of five domains of neurodevelopment and growth in congenital hypothyroidism: Serial 6-year follow-up study of 408 patients

Kyung Jung Mo , Kyo Ha Eun , Ryung Cha Hey , Yong Han Man

Background: There is a link between congenital hypothyroidism (CH) and neurodevelopmental abnormalities, but no longitudinal studies have yet identified reliable quantifiable measures.Purpose: To evaluate associations between CH and abnormalities in neurodevelopment and growth, and identify the timing of these abnormalities and the best time for intervention.Methods: Data from the ...

hrp0097p1-395 | Thyroid | ESPE2023

Thyroid Storm with Diabetes Insipidus: Management of A Rare Endocrine Presentation In A Child

Agrawal Pankaj , R Kapoor Ritika , R Buchanan Charles , Bhushan Arya Ved

Introduction: Thyroid storm is an acute, life-threatening, emergency in children with thyrotoxicosis. It is extremely rare and could be an initial presentation in previously undiagnosed children. Thyroid storm with diabetes insipidus (DI) has been reported in adults, but no cases have been reported in children. We herein report a child with thyroid storm with transient central DI.Case Report: A 7-year-old girl, presented...

hrp0097p1-396 | Thyroid | ESPE2023

Hyperfunctioning follicular adenoma in a 9-year-old boy with Prader-Willi Syndrome

Toscano Fabio , Moleti Mariacarla , Aversa Tommaso , Campenni Alfredo , Fadda Guido , Dionigi Gianlorenzo , Romeo Carmelo , Wasniewska Malgorzata , Corica Domenico

Background: Thyroid nodules in children are less common than in adult but are about two-to three-fold at risk of being malignant compared to adults. Plummer's adenoma is a very rare occurrence in pediatrics; there is no literature evidence of this diagnosis in Prader-Willi Syndrome (PWS).Case Presentation: A 9-year-old boy, followed at our Pediatric Endocrinology Outpatients Clinic for PWS (maternal uniparental diso...

hrp0097p1-397 | Thyroid | ESPE2023

Increased frequency of Grave’s Disease during COVID-19 pandemic

Kosteria Ioanna , Athanasouli Fani , Dikaiakou Eirini , Leka-Emiris Sofia , Papadopoulou Katerina , Fakiolas Stefanos , Kafetzi Maria , Vakaki Marina , Vlachopapadopoulou Elpis-Athina

Introduction: Increased frequency of Grave’s disease (GD) has been reported both in adults and youth during the COVID-19 pandemic. Aim: To compare the frequency of GD prior and during the COVID-19 pandemic.Methods: Retrospective analysis of children diagnosed with GD over the last 13 years in our Department.Results: A total of 22 children (31.8% boys) with a mean age of 10.55...

hrp0097p1-398 | Thyroid | ESPE2023

Positive predictive value of dried blood sampling of TSH in diagnosing congenital hypothyroidism in neonates born at a tertiary care hospital.

Ahmed Khan Wasif , Naz Fizzah , Arif Muzna , Nisar Imran , Nuzhat Humayun Khadija

Background: In children, untreated Congenital Hypothyroidism (CH), can result in permanent neurological defects and growth abnormalities. This can be prevented by early detection and treatment of CH. Newborn screening for CH is considered one of the best tools for the prevention of these long-term complications. In our setting, we use heel-stick dried blood sample TSH (DBS-TSH) as a screening tool to detect CH. The DBS-TSH cut-off level is critical to ensuring...

hrp0097p1-583 | Thyroid | ESPE2023

Was newborn screening for congenital hypothyroidism affected by COVID19 lockdown?

Vitale Laura , Esposito Mariela , Francesca Jesica , Victoria Fasano María , Balbi Viviana , Tournier Andrea , Borrajo Gustavo , González Verónica , Morín Analía

Mandatory lockdown during COVID 19 pandemic obstaculized access to medical attention. Newborn screening (NBS) for congenital hypothyroidism (CH) in Buenos Aires province has been obligatory since 1995 and performed sustainedly. CH causes mental delay if not diagnosed and treated early.Objectives: The aim of this study was to determine if mandatory lockdown changed time of established NBS diagnosis steps.Mat...

hrp0097p1-584 | Thyroid | ESPE2023

National multi-center study of reevaluation of thyroid function in premature infants of less than 32 weeks of gestation and/or less than 1500g admitted to neonatal units

Campos-Martorell Ariadna , Ares Segura Susana , J Chueca Gandulain Maria , Grau Bolado Gema , Navarro Constanza , Serrano Costa Loreto , Gale Pola Ines , Fernandez Vallespin Laura , Pellicer Casanova Laura , Montaner Ramon Alicia , Puig Amoros Elisabet , Mora Sitja Marina , Rodriguez Amparo , Casano-Sancho Paula

Preterm and low birth weight(LBW) newborns are at risk of thyroid dysfunction during a critical period for neurodevelpment and this dysfunction can be missed in congenital hypothyroidism screening program(CHSP). Consequently, reassessment of thyroid function has been promoted in neonatal units, added to CHSP.Objectives: To evaluate prevalence and risk factors of thyroid dysfunction in≤32weeksGA and/or 1500g newborn, and compare differ...

hrp0097p1-585 | Thyroid | ESPE2023

Papillary thyroid carcinoma incidentally discovered in young patients - a case series

Grosu Iustina , Dumitrache Sabina-Maria , Zubaci Ana , Stan Raluca , Cima Luminita-Nicoleta , Vasilache Simona , Martin Sorina-Carmen , Sirbu Anca-Elena , Soare Iulia , Barbu Carmen-Gabriela , Miron Adrian , Terzea Dana , Fica Simona

Introduction: Thyroid carcinoma in pediatric and young adult population presents contradictory features: it has higher rates of multifocal disease, local and distant metastasis and reccurence compared to the adult population, yet the 5-year survival rate is 98%. The rising incidence seen recently cannot be entirely explained by overdiagnosis, as increasing rates of advanced-stage disease are also observed. The rise consists primarily of papillary thyroid carci...

hrp0097p1-586 | Thyroid | ESPE2023

Hyperthyroidism caused by severe bacterial infection

Flury Monika , Gita Gemulla , Reichardt Susen , Stamos Kristina , Taut Heike , Hahn Gabriele , Huebner Angela

We report on a nearly 4-year-old girl who presented to the emergency room of our paediatric clinic with high fever and poor general condition, swelling of the neck and swallowing difficulties. Laboratory chemistry showed a marked hyperthyroid metabolic state, so that initially a thyrotoxic crisis in Graves' disease was considered (TSH 0.03 mU/L (-), fT4 28.10 pmol/l (+)). Therefore, a short-term therapy with thiamazole was given. The thyroid autoantibodies were negative. ...

hrp0097p1-587 | Thyroid | ESPE2023

Analysis of disease types and prognosis of children with nonthyroid illness syndrome

Gou Peng , Cheng Xinran

Objective: The purpose of this article is to retrospectively summarize the disease types and prognosis analysis of children's nonthyroid illness syndrome (NTIS), improve the diagnostic awareness of children's NTIS, and explore whether thyroxine replacement therapy is required or whether the body has a self-healing trend.Methods: The clinical data of 47 cases (32 males and 15 females) of NTIS diagnosed in variou...

hrp0097p1-588 | Thyroid | ESPE2023

The effect of gestational Graves’ disease on the mother-infant dyad: a retrospective observational cohort study

Cohen-Sela Eyal , Brener Avivit , Raviv Orian , Yackobovitch-Gavan Michal , Almashanu Shlomo , Marom Ronella , Anteby Matan , Hiersch Liran , Lebenthal Yael

Context: Pregnancy and parturition involve a complex interplay between maternal health and that of her offspring. Graves’ disease and its management have been associated with adverse pregnancy, labor and delivery, as well as neonatal outcomes. Adaptation of the hypothalamic-pituitary-thyroid axis can be reflected by measuring thyroid function levels in newborn screening (NBS).Objective: To investigate the character...

hrp0097p1-589 | Thyroid | ESPE2023

Thyrotropin receptor stimulating antibodies in pediatric patients with Graves’ diseases using ultra-rapid turbo bioassay

Bossowski Artur , Hatun Burak , Sawicka Beata , Stożek Karolina , Bossowski Filip , J Kahaly George

Background: Thyrotropin receptor (TSH-R) stimulating autoantibodies (TSAb) are present in 90-100% of patients with Graves’ disease (GD). TSAb are functional, impact thyroid function, and are clinically relevant. This study we performed in a pediatric patients with dynamic of Graves’ disease before and during methimazole therapy and in patient with Hashimoto’s thyroiditis using a novel and ultra-rapid TSAb andTBAb bioassay.<p class="abstex...

hrp0097p1-590 | Thyroid | ESPE2023

Predictors of permanent and transient congenital hypothyroidism with eutopic thyroid gland

Expósito Raspeño Mónica , Sánchez Escudero Verónica , García Lacalle Concepción , Marqués Cabrero Araceli , Remedios Mateo Laura , García Cuartero Beatriz , González Vergaz Amparo

Introduction: An increase in the incidence of congenital hypothyroidism (CH) with eutopic gland has been reported worldwide due to neonatal screening programs. Several studies have recently reported factors useful for predicting permanent CH (P-CH).Objectives: To determine predictive factors that could distinguish between permanent and transient CH (T-CH) in patients with eutopic thyroid gland and normal neonatal screeni...

hrp0097p1-591 | Thyroid | ESPE2023

Health-Related Quality of Life in Patients Diagnosed with Childhood Primary Hyperthyroidism

Pitupan Pakanut , Dejkhamron Prapai , Boonchooduang Nonglak , Puttawong Dolrutai , Wongsa Danil , Unachak Kevalee , Wejaphikul Karn

Background: Hyperthyroidism is a common condition in general pediatric practice. Several adult studies show hyperthyroidism affects health-related quality of life (HRQoL). However, information regarding HRQoL in the pediatric population is limited.Objectives: To evaluate HRQoL and psychosocial functioning of patients diagnosed with childhood primary hyperthyroidism compared with healthy controls and to identify the possi...

hrp0097p1-592 | Thyroid | ESPE2023

Effect of iodinated contrast on the thyroid function in young children

Wing Kei Ng Carol , Kan Elaine , Ling Joanna Tung Yuet

Background: Hypothyroidism is a well-known treatable cause of global developmental delay in developing children. In recent years contrast imaging studies are much more commonly employed as diagnostic means in the treatment of various pediatric conditions. In 2022, the FDA issued a warning recommending thyroid function monitoring in babies and young children who receive injections of iodine-containing contrast media(ICM) for medical imaging. They recommend the ...

hrp0097p1-593 | Thyroid | ESPE2023

Congenital malformations in permanent and transient congenital hypothyroidism – prevalence and etiology

Ouarezki Yasmina , Shepherd Sheila , Jones Jeremy , Abubaker Alghanay A , Smith Sarah , Shaikh Guftar , Donaldson Malcolm

Background: An increased prevalence of extra-thyroidal congenital malformations in infants with congenital hypothyroidism (CH) is well established. However, accurate estimation of prevalence figures requires careful distinction between permanent and transient CH. Moreover, the mechanisms resulting in congenital malformations are not well understood.Study aim: To estimate the prevalence of cardiac, extra-cardiac and/or sy...

hrp0097p1-594 | Thyroid | ESPE2023

The relation between psychiatric symptoms and quality of life in children with Graves’ Disease

Yazkan Akgul Gozde , Koprulu Ozge

Introduction: Graves’ disease (GD) is the most common cause of the hyperthyroidism in children and adolescents. Patients may present with norological, ophtalmological, cardiovascular and psychiatric symptoms. The aim of this study is to present the sociodemographic data (age, gender, etc.), clinical findings, quality of life and psychiatric symptoms of the children diagnosed with Graves’ disease and compare these data with the control group matched...

hrp0097p1-595 | Thyroid | ESPE2023

A Case report of papillary thyroid carcinoma diagnosed at an early age

Aydın Behram Bilge , Donbaloğlu Zeynep , Barsal Çetiner Ebru , Singin Berna , Karagüzel Güngör , Ünver Tuhan Hale , Parlak Mesut

Introduct&idot;on: Thyroid cancers are rare malignancies in childhood and their incidence is between 1.5-3% among all childhood cancers. Papillary thyroid cancer (PTC) constitutes more than 90% of childhood thyroid cancers. Risk factors for thyroid cancer include; There are iodine deficiency, radiation exposure, radiotherapy to the head and neck region, and genetic predisposition. We will present an 8-year-old case who presented with a complaint of neck swelli...

hrp0097p1-596 | Thyroid | ESPE2023

Graves Disease - Longer Term Impact on BMI

Kanaskar Suniva , Lane Laura , Ashokkumar Ashmethaa , Bignell Henry , Mohammed Zainab , Boelaert Kristien , Cheetham Timothy , Dias Renuka

Background: Graves’ Disease (GD) is the most common cause of hyperthyroidism in children and develops because of stimulation of the thyroid gland by TSH receptor auto-antibodies (TSHR Ab). An increased risk of obesity has been described in both adults and children following initiation of anti-thyroid drug (ATD) therapy but the longer term impact of GD and it’s treatment on physique in children is unclear.Aims:</strong...