ESPE Abstracts

Objective: The purpose of this article is to retrospectively summarize the disease types and prognosis analysis of children's nonthyroid illness syndrome (NTIS), improve the diagnostic awareness of children's NTIS, and explore whether thyroxine replacement therapy is required or whether the body has a self-healing trend.

Methods: The clinical data of 47 cases (32 males and 15 females) of NTIS diagnosed in various wards of ordinary children in our hospital from January 2019 to December 2021 were collected, and the diseases causing NTIS in children were counted. 61 normal children were taken as the control group. The thyroid gland function was followed up to one year after discharge. T test was used to compare the count data, and P < 0.05 was statistically significant.

Results: The order of diseases leading to children's NTIS was severe infection (sepsis, sepsis, severe pneumonia, etc.), Chronic kidney disease, childhood leukemia and premature birth, which were different from those of adults. The data show that, except for premature infants, the thyroid function of children of all ages recovered with the recovery and recovery of basic diseases after discharge from NTIS, and thyroxine replacement therapy was not started during the course of the disease. In the preterm infants group, thyroid hormone replacement therapy was initiated during hospitalization.

Conclusion: The decrease of thyroid hormone level in children with critical illness is an adaptive protection.