The Value of using IGF1/Growth Hormone Peak Ratio in Children with Idiopathic Short Stature

Ashraf Soliman; Fawzia Alyafei; Sohair Elsideeq; Noor Hamed; Shayma Ahmed; Nada Alaaraj

Introduction: Stimulated GH peak values have been shown to correlate well with nocturnal GH peak values and with nocturnal mean GH values. In addition, the expression level of serum IGF-1 in ISS has been shown to be significantly lower than that in normal children despite their normal GH peak response to provocation.

Objectives: To investigate the value of using the IGF1/GH peak ratio in the anthropometric assessment of children with idiopathic short stature (ISS).

Methods: 20 short children with ISS (HtSDS < -2, with normal GH response to provocation) were randomly selected. Their IGF1 level and their peak GH response to provocation were analyzed in relation to their growth data for 1 year of follow-up. followed for 1 year.

Results: The growth and hormonal data of children with ISS are presented in Table 1:


	Age1	WT1	HT1	HTSD1	BMI1	BMISD1	MPHSD	IGF1-1	GH-P	IGF1/GHP Ratio
Mean	9.6	23.6	122.9	-2.1	15.2	-1.1	-1	197.7	18.1	10.4
SD	2.8	7.2	15.6	0.5	1.5	0.8	0.7	126.5	5.8	9.0
	Age2	WT2	HT2	HTSD2	BMI2	BMISD2	Wt gain g / day
Mean	10.7	28.5	130.5	-1.8	16.3	-0.7	12.6
SD	2.6	8.2	14.2	0.4	1.8	0.7	7.9

Table 2 IGF1/GHP ratio correlation with the growth parameters
	Age 1	HtSDS1	BMI	BMI SDS	IGF-I	IGF1SDS	GH-P	IGF1/GHP	Age2	HtSDS2	wt gain g/d	Delta BMI
Age 1	1.00
HtSDS1	0.37	1.00
BMI	0.57	0.19	1.00
BMI SDS	0.03	0.00	0.69	1.00
IGF-I	0.57	0.57	0.51	0.17	1.00
IGF1SDS	0.18	0.68	0.26	0.21	0.86	1.00
GH-P	-0.19	-0.30	-0.27	-0.13	-0.23	-0.30	1.00
IGF1/GHP	0.53	0.58	0.48	0.40	0.94	0.83	-0.33	1.00
Age2	0.99	0.35	0.59	0.05	0.49	-0.10	-0.19	0.45	1.00
HtSDS2	0.41	0.83	0.35	0.27	0.72	0.76	-0.30	0.63	0.39	1.00
wt gain g/d	0.62	-0.23	0.67	0.25	-0.03	-0.37	-0.36	0.35	0.62	0.08	1.00
Delta BMI	0.11	0.12	0.44	-0.22	0.35	0.04	-0.50	0.36	0.13	-0.04	0.51	1.00
IGF1/GHP ratio highly correlated with the growth parameters (HtSDS, BMI, BMISD) before and after a year of follow-up. In addition, IGF1/GHP ratio correlated significantly with weight gain/day and with delta- BMI at 1 year of follow-up.

Conclusion: The IGF1/GHP ratio correlates significantly with the weight and height growth parameters as well as the linear growth, and weight gain in children with ISS.

ESPE Abstracts

P2-48