Previous issue | Volume 97 | ESPE2023

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

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The 61st ESPE Annual Meeting will now be taking place in The Hague, The Netherlands

Rapid Free Communications

Fat, metabolism and obesity 2

hrp0097rfc8.1 | Fat, metabolism and obesity 2 | ESPE2023

A novel heterozygous likely pathogenic variant in GNB1 causing hyperphagia, severe early onset obesity and neurodevelopmental disorder

Karantza Maria , Hun Seo Go , Hyun Seong-In , Lee Hane , Kitsiou Sophia , Michala Lina , Kostopoulou Eirini

The proband is a 12 yr old Caucasian European girl with grade 3 obesity, developmental delay and hyperphagia. She was born at term via an uncomplicated pregnancy and exhibited neonatal hypotonia, difficulty feeding, failure to thrive and delayed attenuation of milestones. At the age of 2 years she started developing hyperphagia and rapid excessive weight gain. Molecular analysis for Prader Willi syndrome and array CGH were negative. At the age of 10 yrs she was diagnosed with ...

hrp0097rfc8.2 | Fat, metabolism and obesity 2 | ESPE2023

Acute rise of leptin after five days of dexamethasone and its association with hunger, fat mass, sleep and fatigue, in children with acute lymphoblastic leukemia

van Hulst Annelienke , Verwaaijen Emm , van den Berg Sjoerd , van Litsenburg Raphaele , Grootenhuis Martha , Fiocco Marta , Neggers Sebastian , van den Heuvel-Eibrink Marry , van den Akker Erica

Background & Aims: Children with acute lymphoblastic leukemia (ALL) frequently receive high doses dexamethasone during treatment, which may induce acute side effects. The aims of the current study were to determine the influence of a five-day dexamethasone course on changes in leptin, fat mass, body mass index (BMI), hunger, sleep and fatigue and to explore the associations between these changes.Methods: Pediatric AL...

hrp0097rfc8.3 | Fat, metabolism and obesity 2 | ESPE2023

Higher levels of serum α-Klotho are longitudinally associated with less visceral fat accumulation in apparently healthy girls experiencing weight gain

Puerto-Carranza Elsa , Mas-Parés Berta , Gómez-Vilarrubla Ariadna , Díaz-Roldán Ferran , Riera-Pérez Elena , de Zegher Francis , Ibañez Lourdes , Bassols Judit , Carreras-Badosa Gemma , López-Bermejo Abel

Introduction: Klotho is an anti-aging protein that reduces adiposity and increases caloric expenditure, among others. Although associations between secreted α-Klotho levels and obesity have been described, its relationship with central obesity and visceral fat accumulation during childhood is poorly understood. Our objective was to study the longitudinal associations between serum α-Klotho concentrations and obesity parameters in apparently healthy...

hrp0097rfc8.4 | Fat, metabolism and obesity 2 | ESPE2023

Understanding the genetics of early onset obesity in a cohort of children from Qatar

Mohammed Idris , Haris Basma , Al-Barazenji Tara , Vasudeva Dhanya , Tomei Sara , Al Azwani Iman , Dauleh Hajar , Shehzad Saira , Chirayath Shiga , Mohamadsalih Ghassan , Petrovski Goran , Khalifa Amel , love Donald , Al-Shafai Mashael , Hussain Khalid

Context: Monogenic obesity (MO) is a rare form of obesity due to pathogenic variants in genes implicated in the leptin-melanocortin signaling pathway and accounts for around 5% of severe early-onset obesity. Mutations in the MC4R and Leptin genes are the commonest causes of MO. Determining the genetic causes has important clinical benefits as novel therapeutic interventions were developed for some forms of MO.Objective:<...

hrp0097rfc8.5 | Fat, metabolism and obesity 2 | ESPE2023

Effects of leptin knockdown on a human preadipocyte model

Fuchs Lasse , Jasaszwili Mariami , Richter Sandy , Kirstein Anna , Engelberger Felipe , Künze Georg , Meiler Jens , Lemke Johannes , Kiess Wieland , Le Duc Diana , Garten Antje

Obesity presents a major worldwide challenge, due to its numerous, severe adverse effects on health. This leads to a necessity to further investigate the mechanisms underlying lipid accumulation. The adipocytokine leptin may contribute to this process. While there already has been thorough research into central leptin action, deepening our understanding of leptin’s effects on whole-body energy homeostasis, relatively little is known about its auto- and paracrine effects....

hrp0097rfc8.6 | Fat, metabolism and obesity 2 | ESPE2023

Leukocytes and Neutrophil–Lymphocyte Ratio as Indicators of decreased insulin sensitivity in NGT Overweight and Obese Children with high 1-hour post-load plasma glucose levels

Mastromauro Concetta , Lauriola Federico , Matonti Lorena , Trisi Giulia , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Introduction: Obese children with normal glucose tolerance (NGT) but with 1-hour post-load plasma glucose (1hPG) ≥ 132.5 mg/dl are at higher risk of developing type 2 diabetes (T2D) and cardiometabolic complications. In addition, new markers of systemic inflammation derived from blood cell count could be used as indicators of insulin resistance, thus predicting worse metabolic profile.Objective: The aim of our study w...