ESPE2023 Rapid Free Communications Fat, metabolism and obesity 2 (6 abstracts)
Higher levels of serum α-Klotho are longitudinally associated with less visceral fat accumulation in apparently healthy girls experiencing weight gain
Elsa Puerto-Carranza 1 , Berta Mas-Parés 2 , Ariadna Gómez-Vilarrubla 3 , Ferran Díaz-Roldán 1 , Elena Riera-Pérez 4 , Francis de Zegher 5 , Lourdes Ibañez 6 , Judit Bassols 3 , Gemma Carreras-Badosa 2 & Abel López-Bermejo 1,2
1Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain, Girona, Spain. 2Pediatric Endocrinology Research Group, Girona Biomedical Research Institute, Girona, Spain. 3Maternal-Fetal Metabolic Research Group, Girona Biomedical Research Institute, Girona, Spain. 4Pediatrics, Salut Emporda Fundation, Figueres, Spain. 5Department of Development & Regeneration, University of Leuven, Leuven, Belgium. 6Sant Joan de Déu Children’s Hospital Pediatric Research Institute, University of Barcelona, Barcelona, Spain
Introduction: Klotho is an anti-aging protein that reduces adiposity and increases caloric expenditure, among others. Although associations between secreted α-Klotho levels and obesity have been described, its relationship with central obesity and visceral fat accumulation during childhood is poorly understood. Our objective was to study the longitudinal associations between serum α-Klotho concentrations and obesity parameters in apparently healthy children.
Subjects and Methods: We studied a cohort of 208 apparently healthy school-age children (107 girls and 101 boys) assessed at baseline (mean age 8.5 ± 1.8 years) and at follow-up 4 years later. Serum α-Klotho concentrations were measured at baseline in all subjects. Obesity parameters, such as BMI, waist circumference, body fat mass, visceral fat mass, triglyceride levels, HOMA-IR index, and C-reactive protein were studied. Boys and girls were classified into 3 groups based on weight gain between baseline and follow-up visits (BMI increase greater than 0.35 SD, no BMI change, or BMI decrease greater than 0.35 SD).
Results: In girls (n=107), we observed negative associations of serum α-Klotho protein with BMI, waist circumference, body fat mass, visceral fat mass, HOMA IR index, and C-reactive protein at baseline and also at follow-up, which were not observed in boys. In the subgroup analysis, negative associations of α-Klotho and obesity parameters were more evident in girls who exhibited weight gain [increase in BMI greater than 0.35 SD]. In such girls, multivariate regression analyses (adjusting for age and baseline weight/height ratio) showed that α-Klotho protein was negatively associated at follow-up with BMI, waist circumference, and visceral fat mass (P=0.03 to 0.003). For each 1 SD-increase in baseline α-Klotho, follow-up waist circumference decreased by 4.15 cm and visceral fat mass by 1.38 mm.
Conclusions: In school-age girls, serum α-Klotho concentrations are longitudinally related to a more favorable metabolic profile. In girls experiencing weight gain, α-Klotho may prove to be a protective factor against the accumulation of visceral fat.
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