Previous issue | Volume 97 | ESPE2023

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

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The 61st ESPE Annual Meeting will now be taking place in The Hague, The Netherlands


Neonatal endocrinology

hrp0097s6.1 | Neonatal endocrinology | ESPE2023

Unravelling the role of epigenetics in reproductive adaptations to early-life environment

Melamed Philippa

Adult reproductive function is affected by early life environments and experiences, pointing to a possible role for epigenetic modifications in directing an adaptive response. Using mouse and cellular models, we have been studying the mechanisms underlying the shorter reproductive lifespan experienced by Bangladeshi women who grew up in Bangladesh as opposed to the UK, a phenotype associated specifically with the greater immune challenges in Bangladeshi childhood and altered D...

hrp0097s6.2 | Neonatal endocrinology | ESPE2023

Abstract unavailable...

hrp0097s6.3 | Neonatal endocrinology | ESPE2023

The developing HPA axis: establishing diurnal variation in cortisol secretion

Finken Martijn

In adults and older children with adrenal insufficiency, hydrocortisone replacement therapy is based on the assumption that the secretion of cortisol follows a diurnal pattern, with a peak in the early morning, a gradual decline over the day and a nadir at midnight. However, replacement therapy with multiple daily doses of hydrocortisone is unable to exactly match the normal diurnal rhythm of cortisol secretion from an intact hypothalamus-pituitary-adrenal (HPA) axis, with con...