ESPE2023 Poster Category 1 Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology (56 abstracts)
Ovarian Reserve in Children with Juvenile İdiopathic Arthritis Using Biologic Disease-Modifying Anti-Rheumatic Drugs
Yavuz Özer 1 , Mehmet Yıldız 2 , Hande Turan 1 , Gürkan Tarçın 1 , Dilek Bingöl Aydın 1 , Aybüke Günalp 2 , Fatih Haşlak 2 , Elif Kiliç Konte 2 , Esma Aslan 2 , Oya Koker 2 , Elvan Bayramoğlu 1 , Sezgin Şahin 2 , Amra Adrovic 2 , Kenan Barut 2 , Özgür Kasapçopur 2 & Olcay Evliyaoğlu 1
1Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Pediatric Endocrinology, Istanbul, Turkey. 2Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Department of Pediatric Rheumatology, Istanbul, Turkey
The aim of the study is to assess the effect of juvenile idiopathic arthritis (JIA) and biologic disease-modifying anti-rheumatic drugs (bDMARD) on ovarian reserve in children. A cross-sectional study was performed from March 2021 to March 2022 and included 81 patients with JIA and 49 healthy children. Serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol levels were analyzed using electrochemiluminescence methods. The mean of current age (13.5±3.2 vs. 14.4±2.4 years), height SDS (-0.35±1.18 vs. -0.44±0.94), BMI SDS (0.12±1.33 vs. 0.25±1.28) and the median weight SDS [-0.13 (-2.27- 3.23) vs. -0.52 (-3.4- 3.3)] were similar in JIA patients and controls (p > 0.05). Patients with JIA were divided into two groups according to their treatment regimens: treated with methotrexate (MTX) (biologic naive) (n=32) and treated with MTX plus bDMARDs (n=49). No significant differences were detected between the 3 groups regarding menarche age, menstrual cycle length, and flow duration (for all p > 0.05). The median serum concentration of AMH was 2.94 (1.12-7.88) ng/ml in the control group, 3.02 (0.36-8.54) ng/ml in the biologic naïve group and 3.01 (0.99-8.26) ng/ml in MTX plus bDMARDs group. There were no significant differences between 3 groups according to serum AMH, FSH, LH, and estradiol levels (P>0.05). Biologic DMARDs are reassuring in terms of ovarian reserve in girls with JIA and demonstrate that AMH is unaffected by treatment. Prospective studies with larger sample sizes are needed to confirm our findings and to evaluate the impact on the future fertility of patients.
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