ESPE Abstracts (2023) 97 P1-445

ESPE2023 Poster Category 1 Fat, Metabolism and Obesity (97 abstracts)

Impact of early-life overweight/obesity trajectory on insulin resistance at age 8: a prospective cohort study

Hye Jin Lee 1 , Yun Jeong Lee 2 , Youn-Hee Lim 3 , Yun-Chul Hong 4 , Choong Ho Shin 2 & Young Ah Lee 2

1Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea, Republic of. 2Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea, Republic of. 3Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 4Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of

Objective: To investigate whether the early-life overweight/obesity trajectory from ages 2, 4, to 8 affects insulin resistance (IR) in 8-year-old prepubertal children.

Methods: From the Environment and Development of Children (EDC) cohort, 262 prepubertal children (147 boys and 115 girls) who visited Seoul National University Children’s Hospital for anthropometric measurements at ages 2, 4 and 8 were included. At age 8, homeostatic model assessment of insulin resistance (HOMA-IR) was calculated as insulin (mIU/ml) × glucose (mg/dl)/405. Normal weight (NW, <85th BMI percentile), overweight (OW, 85–95th BMI percentile), and obese (OB, ≥95th BMI percentile) status from ages 2, 4, to 8 were accessed to define eight OWOB trajectory groups. The relationship of OWOB trajectory groups with glucose and HOMA-IR was analyzed after adjusting for age, sex, prematurity, small for gestational age, parental BMI, and parental education.

Results: NW groups at age 8 were classified into NW at ages 2, 4, and 8 (all-NW, n= 176), OWOB at age 2 and NW at ages 4 and 8 (OWOB-NW-NW, n= 13), NW-OWOB-NW (n= 9), and OWOB-OWOB-NW (n= 5). OWOB groups at age 8 were categorized into NW-NW-OWOB (n= 33), OWOB-NW-OWOB (n= 7), NW-OWOB-OWOB (n= 8), and OWOB at ages 2, 4, and 8 (all-OWOB, n= 11). For glucose levels, all-OWOB group only showed higher fasting glucose than the all-NW group (P= 0.015). For HOMA-IR, compared to all-NW group, OWOB at age 8 (all-OWOB, NW-OWOB-OWOB, OWOB-NWOWOB, and NW-NW-OWOB groups) or OWOB at age 4 (OWOB-OWOB-NW, and NW-OWOB-NW groups) showed higher HOMA-IR (all P<0.05). However, OWOB at age 2 but NW at age 4 and 8 (OWOB-NW-NW group) showed no difference in HOMA IR compared to all-NW group. Conclusion: Children who were OWOB at age 8 showed higher insulin resistance than NW children at ages 2, 4, and 8. Children who were OWOB at age 4 had higher insulin resistance than all NW children even if they were NW at age 8.

Volume 97

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

European Society for Paediatric Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.